The Effects of Autologous SLET

Status Recruiting

Clinical Trial Summary

This study aims to prospectively evaluate the therapeutic effects of autologous simple limbal epithelial transplantation for patients with limbal stem cell deficiency. The change of visual acuity, quality of life and so on will be monitored before and after surgery.

Clinical Trial Description

Human corneal epithelial cells are stratified squamous cells that cover the corneal surface. These cells are regenerated from cells known as limbal stem cells (LSCs) that grow continuously and proliferate from the limbus. Failure or damage at the limbal zone can occur from hereditary or acquired causes such as ocular burns, trauma, or diseases such as Stevens- Johnson syndrome, leading to limbal stem cell deficiency (LSCD). The treatment of LSCD includes transplantation of healthy limbal tissue or cultured limbal epithelial cells. In the last two decades, cultivated limbal epithelial transplantation (CLET) has been a widely used technique. In 2012, Sangwan and coworkers proposed a novel technique that they named simple limbal epithelial transplantation (SLET) for the treatment of unilateral LSCD1. SLET could have benefits for those centers that do not have the ability to perform cultivated limbal epithelial transplantation (CLET) preparation and could be especially useful for those countries that cannot afford a GMP center. Therefore, SLET is quickly gaining popularity in countries like India. As it is a relatively new technique, its long-term clinical effectiveness (similar to what is observed in CLET) must be noted before determining its actual benefits.Our study aims to prospectively evaluate the therapeutic effects of autologous simple limbal epithelial transplantation for patients with limbal stem cell deficiency. The change of visual acuity, quality of life and so on will be monitored before and after surgery. In this study, the effects of autologous simple limbal epithelial transplantation will be investigated. ;

Study Design

Related Conditions & MeSH terms

Limbal Stem-cell Deficiency

Clinical Trial Details

NCT number	NCT04021875
Study type	Observational
Source	National Taiwan University Hospital
Contact	Wei-Li Chen, phD
Phone	+886223123456
Email	cwlntuh@gmail.com
Status	Recruiting
Phase
Start date	July 5, 2019
Completion date	July 1, 2025

View Details

See also
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Recruiting	`NCT04021134` - The Effects of Allogeneic SLET
Completed	`NCT03226015` - Autologous Oral Mucosa Transplantation for Limbal Stem Cell Deficiency	N/A
Recruiting	`NCT04995926` - Labial Mucosal Epithelium Grafting for Corneal Limbus Substitution	N/A
Completed	`NCT05461469` - CDL Validation Study
Completed	`NCT02415218` - Transplantation of Autologous Oral Mucosal Epithelial Sheets for Limbal Stem-cell Deficiency	Phase 1/Phase 2
Not yet recruiting	`NCT03884569` - Cultivated Limbal Epithelial Transplantation (CLET) for Limbal Stem Cell Deficiency (LSCD)