Limbal Stem-cell Deficiency Clinical Trial
Official title:
Multiple Noninvasive Examination Modality to Evaluate the Severity of Ocular Surface Disorders
NCT number | NCT03594370 |
Other study ID # | 201803133RINC |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | June 8, 2018 |
Est. completion date | May 22, 2019 |
Verified date | May 2019 |
Source | National Taiwan University Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Here the investigators proposed this study to collect cases of different etiologies of ocular surface diseases. With at least one of these four non-invasive examination modalities, the investigators aim to analyze and compare the detecting results. The investigators especially focus on the possibility of using OCT to predict the condition of limbal epithelial stem cells, aiming to use this patient-friendly tool to detect the patient's limbal conditions.
Status | Completed |
Enrollment | 25 |
Est. completion date | May 22, 2019 |
Est. primary completion date | January 31, 2019 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 5 Years and older |
Eligibility |
Inclusion Criteria: - Patient who is able to understand and cooperate with the examination: aged over 5 years. - Patient or the legal representative is able to read and sign an informed consent form. - Patient with one of the diagnosis listed below: 1. limbal insufficiency 2. phlyctenulosis 3. ocular rosacea 4. ocular graft-versus-host disease (GVHD) 5. dry eye syndrome (both aqueous deficiency or increased evaporative forms of dry eyes) 6. other ocular surface diseases (advancing wave-like epitheliopathy, long term use of anti-glaucoma eye drops) Exclusion Criteria - Patients who decline to receive any of the non-invasive examinations mentions in this clinical trial. - Patients younger than 5 years old. |
Country | Name | City | State |
---|---|---|---|
Taiwan | NTUH | Taipei |
Lead Sponsor | Collaborator |
---|---|
National Taiwan University Hospital |
Taiwan,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | limbal structural abnormality | atypical pattern of limbal Palisade of Vogt detected by OCT comparing to normal subjects | assess the OCT limbal image at the baseline |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT03957954 -
Stem Cell Therapy for Limbal Stem Cell Deficiency
|
Phase 1 | |
Recruiting |
NCT05909735 -
Treatment of LSCD With DM
|
Phase 1 | |
Recruiting |
NCT04021134 -
The Effects of Allogeneic SLET
|
||
Recruiting |
NCT04021875 -
The Effects of Autologous SLET
|
||
Completed |
NCT03226015 -
Autologous Oral Mucosa Transplantation for Limbal Stem Cell Deficiency
|
N/A | |
Recruiting |
NCT04995926 -
Labial Mucosal Epithelium Grafting for Corneal Limbus Substitution
|
N/A | |
Completed |
NCT05461469 -
CDL Validation Study
|
||
Completed |
NCT02415218 -
Transplantation of Autologous Oral Mucosal Epithelial Sheets for Limbal Stem-cell Deficiency
|
Phase 1/Phase 2 | |
Not yet recruiting |
NCT03884569 -
Cultivated Limbal Epithelial Transplantation (CLET) for Limbal Stem Cell Deficiency (LSCD)
|