Limbal Stem-cell Deficiency Clinical Trial
Official title:
Multiple Noninvasive Examination Modality to Evaluate the Severity of Ocular Surface Disorders
Here the investigators proposed this study to collect cases of different etiologies of ocular surface diseases. With at least one of these four non-invasive examination modalities, the investigators aim to analyze and compare the detecting results. The investigators especially focus on the possibility of using OCT to predict the condition of limbal epithelial stem cells, aiming to use this patient-friendly tool to detect the patient's limbal conditions.
In vivo confocal microscopy, anterior segment optical coherence tomography, keratograph and
impression cytology are noninvasive, rapid and easily repeatable technique to investigate
ocular surface disorders. In vivo confocal microscopy (IVCM) enables morphological and
quantitative analysis of ocular surface microstructure. Optical coherence tomography (OCT)
allows for imaging of the morphology of biological tissue with micrometer scale resolution at
imaging depths of 1 to 2mm below the tissue surface. [1,2] Anterior segment OCT (ASOCT) has
been developed to evaluate corneal diseases[3-8] in different layers. Keratography includes
noninvasive meibography and tear interferometry. The former demonstrates the morphology of
meibomian glands whereas the later observes quality and quantity of the lipid layer of the
tear film. Impression cytology shows the morphology of the corneal and conjunctival
epithelial cells, their staining behavior, and nuclear/cytoplasmic ratio could be observed in
detail.
Here the investigators proposed this clinical trial to collect cases of different etiologies
of ocular surface diseases. With at least one of these four non-invasive examination
modalities, the investigators aim to analyze and compare the detecting results. The
investigators especially focus on the possibility of using ASOCT to predict the condition of
limbal epithelial stem cells, aiming to use this patient-friendly tool to detect the
patient's limbal conditions.
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