Limbal Stem-cell Deficiency Clinical Trial
Official title:
Autologous Oral Mucosa With Amniotic Membrane Transplantation for Limbal Stem Cell Deficiency: Clinical and Immunohistochemical Study
PURPOSE: To report clinical and histochemical results of oral mucosa graft transplantation in
eyes with limbal stem cell deficiency.
DESIGN: Prospective observational study.
METHODS: 32 eyes of 27 patients with limbal stem cell deficiency underwent direct oral mucosa
graft transplantation with amniotic membrane transplantation with a mean follow-up of 19
months. Clinical course of the disease including emergency surgeries, planned curative
procedures, conjunctival inflammation, acute inpatient treatment and best corrected visual
acuity were assessed at 3 months postoperatively and at last follow up visit. The unneeded
parts of oral mucosa graft were analyzed immunohistochemically with staining for mesenchymal
stem cell markers and pericytes (CD 90, CD 146, CD 166, CD 31, CD 68, protein gene product).
n/a
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