ADHD Clinical Trial
Official title:
Nutritional and Environmental Conditions in Attention Deficit Hyperactivity Disorder
In this study the investigators aim to investigate the relationship between environmental factors, lifestyle and symptoms of Attention Deficit Hyperactivity Disorder (ADHD). Initially the investigators intend to measure the relationship between nutritional quality, exercise and sleep and ADHD symptoms. And then measure whether a change made in the diet can improve the symptoms of ADHD.
The Attention Deficit Hyperactivity Disorder is a neurobiological chronic disorder,
symptomatically evolutionary and of probable genetic transmission that affects between 5 and
10% of the child population.
The current opinion on the etiology of the disorder focuses on a failure in the development
of brain circuits in which inhibition and self-control, critical functions to perform any
task, gets supported. In addition, there is greater evidence of knowledge of the genetic
influence as a major part of the etiology of ADHD. Studies suggest that ADHD is familiar and
that genetic influences may contribute to its etiology from moderate to high phenotypic
expression. Current studies have identified significant associations with several candidate
genes for this disorder, including DAT1, DRD4, DRD5, 5HTT, HTR1B or SNAP25.
Meta-analytical studies are needed to develop a more personalized treatment for ADHD. Other
factors associated with ADHD are inadequate lifestyles by parents, especially during the
gestation period in the case of the mother. ADHD treatment includes the use of medication
and psychosocial and educational support
FOOD, NUTRITION AND ADHD: A NEW PARADIGM OF THERAPY?
Despite the above, with the use of internet many hypotheses have emerged, not yet proven,
many in relation to food of patients with ADHD, in which a single focus is exposed as the
determinant factor: heavy metals; gluten and dairy; additives; or intake of certain
supplements.
The truth is that, neuronal function is strongly influenced by substances in the diet, which
are very important for its functioning. Many micronutrients have been evaluated, including
mainly vitamins B6, B12, B9, D and E along with some minerals like magnesium, selenium and
zinc. Their actions are related to memory, neurotransmitter synthesis and neurological
protection.
Multiple studies have found magnesium deficiency in patients with ADHD, as reported in
relation to other nutrients. What has also led to study specifically the use of
supplementation, in patients with ADHD, with zinc, magnesium, phytochemicals, omega-3
traditional herbs or mixtures of these elements.
OBJECTIVES
- Main objective:
- Rating, by analysis of results, environmental, nutritional and body composition
factors, which may affect the pathogenesis and symptoms of ADHD patients.
- Specific objectives (project sub-lines):
- Heritage and programming: assessing the hereditary role, as the main factor for
the development of ADHD: genetics, nursing, toxic habits in parents and birth
characteristics.
- Diet and physical activity: assessing the role of specific nutrients, eating
patterns, exercise, sedentary lifestyle, leisure type and cognitive entertainment,
in the development of ADHD.
- Body Composition: assessing body fat accumulation and muscle mass, aspects
involved in the metabolism of people with ADHD.
DESIGN
Cross-sectional study of observational, descriptive and comparative cohort. It consists of
volunteer participants, divided into two study groups:
1. cases (ADHD) and
2. controls (healthy, with no ADHD).
For the initial design and protocols main databases have been revised (Scielo, PubMed,
ENBASE...).
Development: An observational retrospective cohort study.
Incidental sample: n = 70-100 (approximately 35-50 subjects per group, of the same age
range).
Inclusion criteria: both genders, ages 8-16 years.
Intervention trial. A personalized diet for patients will be performed. After completion of
the diet, the effect of the intervention on ADHD symptomatology will be measured.
;
Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Supportive Care
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