Fractures, Bone Clinical Trial
Official title:
Factors Associated With Future Fractures in Middle-aged Men and Women. A Prospective Cohort Study From Malmö Dietary Cancer Cohort
From prospectively collected health and life-style data and anthropometric data in the Malmo Diet and Cancer (MDC) cohort identify factors that predicts or are associated with forthcoming fracture in middle-aged men and women.
In adults, the incidence of fractures increases with age. In predisposed individuals, even a
minor trauma can result in a fracture. Such an injury is known as low-energy fracture or
fragility fracture, and the risk increases with age. Fragility fractures may be preventable,
either by changes in lifestyle or by medication of underlying diseases. Fragility fractures
also put a burden both on the affected individual and on society. As the population age, more
individuals are at risk, and the absolute numbers of fragility fractures increase. Therefore,
identification of individuals at risk before fracture occurs would be ideal.In the
prospectively collected Malmo Diet and Cancer (MDC) cohort a large number of health and life
style variables have been gathered from randomly invited men and women in a city of 350,000
inhabitants in the 1990s'. The MDC database the investigators use for this study comprises
30,351 participants. Outcome is updated via crosslinking with the National Patient Register
in Sweden.
MDC PhysFract - investigation of the following factors Socioeconomical factors: Level of
education, employment status in middle age, physical activity / work load, living alone,
stress, number of friends, feeling of loneliness.
Life style factors: Tobacco use, alcohol use. Summary of physical and psychological
well-being.
MDC CardFract - investigation of the following factors Comorbidities: Hypertension,
syncope/orthostatism, diabetes, coronary artery disease, atrial fibrillation, heart failure,
ischemic stroke and others.
Pharmaceutical drugs associated with fracture risk. Cardiovascular blood tests.
MDC HormFract - investigation of the following factors Body composition: Weight at 20 yrs,
weight change pattern, weight difference middle age minus 20 yrs.
Hormonal/gynecological status - women: Date for menarche and menopause, number of children,
intake of oral contraceptives / hormonal replacement therapy, surgical menopause.
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