Lidocaine Clinical Trial
Official title:
Effect of Intravenous Infusion of Lidocaine on Patients Undergoing Radical Resection of Colorectal Tumors
Verified date | January 2022 |
Source | Affiliated Hospital of Nantong University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Colorectal cancer (CRC) is one of the most common malignant tumors in the world. Surgical resection is the main treatment option for colorectal cancer patients. Surgery may enhance or accelerate tumor recurrence and metastasis. Multiple factors in the tumor microenvironment play important roles in tumor recurrence and metastasis, and modulating the tumor microenvironment can inhibit disease progression. Lidocaine has been found to inhibit tumor growth in animal experiments.
Status | Completed |
Enrollment | 100 |
Est. completion date | January 30, 2023 |
Est. primary completion date | December 30, 2021 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 30 Years to 85 Years |
Eligibility | Inclusion Criteria: - colorectal tumor patients Exclusion Criteria: - Weight <45kg and >100kg - Sensitivity or hypersensitivity to lidocaine - Second or third degree heart block - Severe heart failure (ejection fraction < 20%) - History of active rhythm disorder - Acute severe liver and kidney injury - History of uncontrolled seizures - History of acute porphyria. |
Country | Name | City | State |
---|---|---|---|
China | Affiliated Hospital of Nantong University | Nantong | Jiangsu |
Lead Sponsor | Collaborator |
---|---|
Affiliated Hospital of Nantong University |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | the concentration of tumor micrometastasis markers were determined by ELISA | the concentration of tumor micrometastasis markers such as CK20 was determined by ELISA | 3 days after surgery | |
Secondary | the concentration of stress hormones were determined by ELISA | the concentration of EPI and NE were determined by ELISA | 3 days after surgery | |
Secondary | the concentration of inflammatory factor were determined by ELISA | the concentration of IL-6,IL-8,TNF-a were determined by ELISA | 3 days after surgery | |
Secondary | the concentration of angiogenesis factors were determined by ELISA | the concentration of VEGF was determined by ELISA | 3 days after surgery | |
Secondary | the concentration of immune indexes were determined by ELISA | the concentration of B lymphocytes, T lymphocytes, NK cells, macrophages were determined by ELISA | 3 days after surgery |
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