Arrhythmia Clinical Trial
Official title:
The Comparison of Antiarrhythmic and Myocardial Protective Effect Between Lidocaine, Dexmedetomidine, and Their Combined Infusion in Subjects Undergoing Coronary Artery Bypass Graft
The aim of the present study is to compare the antiarrhythmic and myocardial protective effect between lidocaine, dexmedetomidine, and their combined infusion in subjects undergoing coronary artery bypass graft.
Lidocaine has been reported to have an antiarrhythmic and myocardial protective effect. A
previous study has reported that low-dose lidocaine infusion can decrease the incidence of
ventricular fibrillation and tachycardia during the first 24 hours after coronary artery
bypass graft (CABG). A recent study also reported that the lidocaine infusion during CABG
could decrease the myocardial injury by measuring the CK-MB and Troponin-I blood level.
Dexmedetomidine is an alpha-2 agonist and reduces the sympathetic tone and neuroendocrine
stress response. Dexmedetomidine was reported to have a cardioprotective effect by a
previous animal study. However, there was no clinical study evaluating the cardioprotective
effect of dexmedetomidine.
Therefore, we are trying to evaluate and compare the antiarrhythmic and myocardial
protective effect between lidocaine, dexmedetomidine, and their combined infusion in
subjects undergoing coronary artery bypass graft.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor)
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