Treatment Protocols for Patients With Symptomatic Oral Lichen Planus

Status Completed

Clinical Trial Summary

The primary objective of this study was to compare the therapeutic efficacy of clobetasol propionate 0.05% oral gel versus an anti-inflammatory mouthwash in an oral solution for the management of patients suffering from symptomatic OLP. The secondary objective was to analyze which one of the two treatments induced a greater risk of developing side effects.

Clinical Trial Description

Forty patients were assigned (20 patients per group), through a randomized design, to receive clobetasol (clobetasol gel 0.05%), or an anti-inflammatory mouthwash (mouthwash which contains calcium hydroxide, hyaluronic acid, Umbelliferone and Oligomeric Proanthocyanidins) for 3-months. At baseline (T0) and after 3 months (T1), patients were subjected to clinical and oral assessments and were evaluated for the symptoms (Numerical Pain Scale, NRS score) and signs (Thongprasom's score) of OLP. Data were calculated using T-test for the dependent variable, Wilcoxon test and Mann-Witney u test. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04673916
Study type	Interventional
Source	University of Messina
Contact
Status	Completed
Phase	N/A
Start date	June 1, 2019
Completion date	June 25, 2020

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