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NCT02276573 Clinical Trial

Study of Inflammatory Role of Epstein-Barr Virus (EBV) in Atrophic and Erosive Forms of Oral Lichen Planus

Lichen Planus, Oral Clinical Trial

— LICHENVIR  

Official title:
Study of Inflammatory Role of Epstein-Barr Virus (EBV) in Atrophic and Erosive Forms of Oral Lichen Planus

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT02276573
Other study ID # 14-AOI-02
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date March 30, 2015
Est. completion date March 10, 2016

Study information
Verified date November 2023
Source Centre Hospitalier Universitaire de Nice
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Oral lichen planus (OLP) is a chronic inflammatory and relapsing. The average prevalence is 1 to 4%. The clinics forms are many and symptoms are varied. The erosive form, painful and debilitating is characterized by erosive areas, ulcerated on an erythematous base with or without a keratinocyte lichenien network. The literature data moving towards an autoimmune origin, but the pathophysiological mechanisms of OLP remain unknown. This project represents the first part of a comprehensive project to examine the oral pathogenesis of different viruses (Herpes and papillomavirus HPV) and centered on Epstein-Barr Virus (EBV).

Recruitment information / eligibility
Status Completed
Enrollment 13
Est. completion date March 10, 2016
Est. primary completion date March 10, 2016
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Patient = 18 years - Clinical and/or histological diagnosis of erosive or atrophic OLP - No signs of severe dysplasia at the sampling Exclusion Criteria: o immunosuppressive or anti-inflammatory therapies at the inclusion

Study Design

Related Conditions & MeSH terms

Intervention

Biological:
• buccal cavity sample

Locations
Country Name City State
France Hôpital saint Roch Nice

Sponsors (1)
Lead Sponsor Collaborator
Centre Hospitalier Universitaire de Nice

Country where clinical trial is conducted

France, 

Outcome
Type Measure Description Time frame Safety issue
Primary Measure of level of EBV nucleic acids day 1
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