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The Relationship Between White Matter Hyperintensity With Cognition and Emotion

Aged Clinical Trial

Official title:
The Relationship Between White Matter Hyperintensity With Cognition and Emotion

Clinical Trial Summary

White matter hyperintensity (WMH) has been found to be related with cognitive and emotional dysfunction. A presumed mechanism is that WMH disrupts the structural connectivity within a large-scale brain network, thereby impairing the brain's ability to integrate the neural processes efficiently. It is not yet clear, what the pattern of brain network disruption relates to WMH and how the brain network disruption induced by WMH has an effect on cognition and emotion performance. Using multi-model magnetic resonance imaging (MRI) techniques, we aimed to explore the mechanisms of cognitive decline and depression related with brain network dysfunction in patients with WMH, and to provide objective imaging marker for early diagnosis and prevention of WMH associated cognitive decline and depression.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02761148
Study type Observational
Source Zhejiang University
Contact Minming Zhang, Ph.D
Phone 13906520711
Email zhangminming@zju.edu.cn
Status Recruiting
Phase N/A
Start date January 2014
Completion date December 2019
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