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Clinical Trial Summary

The addition of ponatinib to mini-hyper-CVD chemotherapy and venetoclax will improve the complete remission rate in patients with relapsed or refractory T-cell acute lymphoblastic leukemia


Clinical Trial Description

OBJECTIVES The addition of ponatinib to mini-hyper-CVD chemotherapy and venetoclax will improve the complete remission rate in patients with relapsed or refractory T-cell acute lymphoblastic leukemia. Primary Objective: To assess complete remission (CR) / CR with incomplete count recovery (CRi) rate with the combination of Ponatinib and mini-hyper-CVD chemotherapy and venetoclax. Secondary Objectives: To assess the safety of the regimen To assess rate of measurable residual disease (MRD) negative remission To assess duration of response (DOR), progression-free survival (PFS) and overall survival (OS) Exploratory Objectives: To assess the level of phospho-LCK in pretreatment samples and correlation with the To assess expression of BCL-2 family proteins ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05268003
Study type Interventional
Source M.D. Anderson Cancer Center
Contact Jain Nitin, MD
Phone (713) 745-6080
Email njain@mdanderson.org
Status Recruiting
Phase Phase 2
Start date June 7, 2022
Completion date October 5, 2026

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