Leukemia Clinical Trial
Official title:
Next Generation Sequencing (NGS) Approach to Study Known and New Germline Mutations in Familial Acute Myeloid Leukemia and Myelodisplastic Syndromes
The aim of this study is to look for predisposing mutations in patients and relatives affected by AML and MDS with familial history of myeloid or, less frequently, lymphoid malignancies. Taking advantage of a next generation sequencing (NGS) platform, screening for known and unknown mutations potentially associated with the disease will be done. The screening will be performed on affected and unaffected family members, in order to outline new pedigrees that either validate previous findings or constitute novel discoveries.
Status | Recruiting |
Enrollment | 20 |
Est. completion date | December 31, 2023 |
Est. primary completion date | December 31, 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | N/A and older |
Eligibility | Inclusion criteria: Any patient with acute myeloid leukemia (AML) or Myelodisplastic Syndrome (MDS) with: 1. a first- or second-degree relative with Acute leukemia or MDS or other myeloid malignancies 2. a first- or second-degree relative with Lymphoproliferative neoplasms 3. or with clinical features that resemble one of the familial MDS/AML predisposition syndromes: - History of thrombocytopenia and/or a clinical bleeding propensity (as in RUNX1, ANKRD26 or ETV6 germline mutations) - Abnormal nails or skin pigmentation, oral leukoplakia, idiopathic pulmonary fibrosis, unexplained liver disease (as in TERT and TERC germline mutations) - Lymphedema, atypical infections, immune deficiencies (as in GATA2 germline mutations) Exclusion Criteria: 1. any diagnosis other than acute myeloid leukemia (AML) or Myelodisplastic Syndrome (MDS); 2. acute myeloid leukemia (AML) or Myelodisplastic Syndrome (MDS) without a first- or second-degree relative with Acute leukemia or MDS or other myeloid malignancies or without a first- or second-degree relative with Lymphoproliferative neoplasms or with clinical features that resemble one of the familial MDS/AML predisposition syndromes; 3. unability to sign the informed consent |
Country | Name | City | State |
---|---|---|---|
Italy | Chair of Hematology and Bone marrow Transplant Unit | Brescia |
Lead Sponsor | Collaborator |
---|---|
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia |
Italy,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Discovery of predisposing mutations | Screening of tumor and germline DNA for predisposing mutations | After enrollment of the first 10 cases (an avarage of 2 years) |
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