Leukemia Clinical Trial
Official title:
Molecular Taxonomy in Pediatric Cancer- IncRNA Expression in Primary T-ALL
RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory
may help doctors identify and learn more about biomarkers related to cancer
PURPOSE: This laboratory study is looking into RNA in samples from younger patients with
T-cell (T) acute lymphoblastic leukemia (ALL).
OBJECTIVES:
- Characterization of the transcriptomic landscape in diagnosis and relapse of T-cell
acute lymphoblastic leukemia (ALL) and the direct comparison with corresponding
physiological samples (human thymus).
- Perform high-throughput transcriptome ribonucleic acid (RNA) sequencing using matched
diagnostic T-precursor pediatric ALL samples (peripheral blood or bone marrow).
OUTLINE: Archived peripheral blood and bone marrow samples are analyzed for long non-coding
RNA (IncRNA) expression and sequencing.
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Observational Model: Case-Only, Time Perspective: Retrospective
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