Leukemia Clinical Trial
Official title:
S0106B, Stem Cell Origin in AML: Prognostic and Therapeutic Implications
RATIONALE: Studying samples of bone marrow from patients with cancer in the laboratory may
help doctors identify and learn more about biomarkers related to cancer.
PURPOSE: This research trial studies bone marrow samples from women with acute myeloid
leukemia.
OBJECTIVES:
- Estimate the proportion of acute myeloid leukemia (AMLs) that originate in CD33+
precursors or in which uncontrolled growth is limited to CD33+ precursors.
- Explore whether there is an association between the cellular origin of AML (i.e.,
origination in CD33+ precursors or not) and cytogenetic, molecular, and other patient
characteristics.
- Explore whether overall survival (OS), event-free survival (EFS), disease-free survival
(DFS), response rate (RR), or relapse rate is improved for patients with AMLs that
originate in CD33+ precursors or in which uncontrolled growth is limited to CD33+
precursors compared to patients with clonally involved cells not detected.
OUTLINE: Archived bone marrow samples are analyzed for CD33+ progenitors, X-chromosome
inactivation, and somatic mutations (t(8;21), inv(16), FLT3/ITD, NPM1, CEBPA, KIT) by
fluorescence-activated cell sorting, long-term culture in hypoxic condition in
cytokine-containing liquid media, and flow cytometry. Results are then compared with each
patient clinical data.
;
Time Perspective: Retrospective
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