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NCT01500499 Clinical Trial

Role of Biomarkers in Disease Progression in Samples From Patients With Acute Myeloid Leukemia

Leukemia Clinical Trial

Official title:
The Role of AF1q in Progression of Leukemia

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT01500499
Other study ID # AAML12B2
Secondary ID COG-AAML12B2AAML
Status Completed
Phase N/A
First received December 24, 2011
Last updated May 17, 2016
Start date December 2011

Study information
Verified date May 2016
Source Children's Oncology Group
Contact n/a
Is FDA regulated No
Health authority United States: Federal Government
Study type Observational

Clinical Trial Summary

RATIONALE: Studying samples of blood, tissue, and bone marrow from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research trial studies the role of biomarkers in disease progression in samples from patients with acute myeloid leukemia.

Description:

OBJECTIVES:

- To determine the subcellular localization of the MLL-AF1q fusion protein in leukemia cells.

OUTLINE: Cryopreserved specimens are analyzed for MLL-AF1q fusion protein and AF1 gene expression by mass spectrometry, western blot analysis, semi-quantitative PCR, and qPCR.

Recruitment information / eligibility
Status Completed
Enrollment 20
Est. completion date
Est. primary completion date May 2016
Accepts healthy volunteers No
Gender Both
Age group N/A to 30 Years
Eligibility DISEASE CHARACTERISTICS:

- Cryopreserved acute myeloid leukemia specimens

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Study Design

Observational Model: Cohort, Time Perspective: Retrospective

Related Conditions & MeSH terms

Intervention

Genetic:
• gene expression analysis

• gene rearrangement analysis

• polymerase chain reaction

• protein analysis

• western blotting

Other:
• laboratory biomarker analysis

• mass spectrometry

Locations
Country Name City State
n/a

Sponsors (2)
Lead Sponsor Collaborator
Children's Oncology Group National Cancer Institute (NCI)

Outcome
Type Measure Description Time frame Safety issue
Primary Subcellular localization of the MLL-AF1q fusion protein in leukemia cells No
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