Leukemia Clinical Trial
Official title:
Xenotransplantation of Primary Leukemia Samples Into Zebrafish
Verified date | May 2016 |
Source | Children's Oncology Group |
Contact | n/a |
Is FDA regulated | No |
Health authority | United States: Federal Government |
Study type | Observational |
RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory
may help doctors learn more about cancer and the development of drug resistance in patients.
It may also help doctors find better ways to treat cancer.
PURPOSE: This research trial is studying samples from patients with leukemia.
Status | Completed |
Enrollment | 10 |
Est. completion date | |
Est. primary completion date | May 2016 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | N/A to 30 Years |
Eligibility |
DISEASE CHARACTERISTICS: - Samples of blood and tissue cells from patients diagnosed with myeloid disease including the following subtypes: - Chronic phase chronic myeloid leukemia (CML), to complement initial studies in the K562 CML cell line - Acute promyelocytic leukemia (APL), to complement initial studies in the NB4 APL cell line - Acute myeloid leukemia (AML) expressing the t(8;21)(q22;q22) translocation, which occurs in approximately 12% of pediatric AML and is associated with good prognosis - AML expressing 5q- or monosomy 7, associated with a poor prognosis - AML expressing the fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD), associated with a poor prognosis PATIENT CHARACTERISTICS: - Not specified PRIOR CONCURRENT THERAPY: - Not specified |
Observational Model: Case-Only, Time Perspective: Retrospective
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Children's Oncology Group | National Cancer Institute (NCI) |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Primary human leukemia samples capable to survive and proliferate in the zebrafish embryo | No | ||
Primary | In vivo confirmation of anti-proliferative or toxic effects of known chemotherapeutic agents on the transplanted cells | No | ||
Primary | Effects of novel anticancer drugs and/or their combinations on individual samples | No |
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