Leukemia Clinical Trial
Official title:
Genomic and Proteomic Profiling of Childhood AML
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help
doctors learn more about changes that occur in DNA and identify biomarkers related to
cancer.
PURPOSE: This research study is looking at biomarkers in tissue samples from young patients
with acute myeloid leukemia previously enrolled on clinical trial POG-9421.
OBJECTIVES:
- To profile basal and potentiated phospho-protein networks (PPPNs) using tissue samples
from pediatric patients with de novo acute myeloid leukemia (AML) previously enrolled
on clinical trial POG-9421.
- To classify AML-based signal transduction mechanisms.
- To correlate profiles of basal and PPPNs with specific molecular lesions (e.g.,
FLT3-ITD, NPM, WT1, c-kit, CEPBα, PASGΔ75, and karyotype) and profiles of gene
expression in tumor tissue samples.
OUTLINE: Banked tissue samples are collected for laboratory studies, including
phospho-protein signaling and gene expression profiling studies.
;
Observational Model: Cohort, Time Perspective: Retrospective
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