Leukemia Clinical Trial
Official title:
Genome-Wide Interrogations in Childhood Acute Lymphoblastic Leukemia (ALL)
RATIONALE: Studying samples of blood and bone marrow from patients with cancer in the
laboratory may help doctors learn more about changes that occur in DNA and identify
biomarkers related to cancer. It may also help doctors predict how well patients will
respond to treatment.
PURPOSE: This research study is looking at DNA in blood and bone marrow samples from young
patients with acute lymphoblastic leukemia.
OBJECTIVES:
- To manage and oversee determination of genome-wide genotypes using common laboratory
methodologies for young patients with newly diagnosed acute lymphoblastic leukemia
(ALL).
- To provide a mechanism for storing, distributing, and tracking usage of blast and
germline genomic information for approved projects.
- To facilitate research for childhood ALL using genome-wide germline and blast data to
identify genetic variations associated with important phenotypes: treatment response
(e.g., relapse risk, minimal residual disease status), adverse effects (e.g.,
osteonecrosis, infection risk, neurotoxicity), risk of ALL, and risk of ALL subtypes
(e.g., TEL/AML1, BCR/ABL, T-cell).
- To provide a data resource, that can be linked with additional tumor cell information,
to better characterize the biology and subtypes of childhood ALL.
OUTLINE: This is a multicenter study.
DNA from previously collected and banked blood and bone marrow samples is utilized for
genome-wide genotyping.
Genotype data is only used to examine specific questions related to the epidemiology and
etiology of leukemia, response of leukemia to treatment, risk of recurrence, risk for
development of side effects, and complications related to treatment.
;
Observational Model: Case-Only, Time Perspective: Retrospective
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