Leukemia Clinical Trial
Official title:
S9007, Cytogenetic Studies in Leukemia Patients
RATIONALE: Studying samples of bone marrow and blood from patients with cancer in the
laboratory may help doctors learn more about changes that occur in DNA and identify
biomarkers related to cancer. It may also help doctors predict how patients will respond to
treatment.
PURPOSE: This research study is looking at bone marrow and blood samples from patients with
leukemia or other hematopoietic cancers.
Primary objective:
* Maintain and expand a database of cytogenetic information on leukemia patients.
Other objectives as funding permits:
- Determine the frequency and prognostic significance of cytogenetic abnormalities in
bone marrow or peripheral blood cells in patients with leukemia prior to treatment and
at various times during treatment undergoing treatment on a companion clinical trial.
- Correlate the presence of cytogenetic features with clinical, pathophysiological,
cellular, and molecular characteristics in these patients.
- Provide quality control for all Southwest Oncology Group cytogenetic data.
OUTLINE: Bone marrow and/or peripheral blood samples from patients on specific treatment
protocols for leukemia are analyzed for cytogenetic abnormalities. Samples from patients
with chronic lymphocytic leukemia (CLL) are analyzed for trisomy 12 by fluorescence in situ
hybridization and conventional cytogenetics.
PROJECTED ACCRUAL: Approximately 2,500 patients (1,200 with first-line acute myeloid
leukemia [AML], 500 with first-line acute lymphoblastic leukemia [ALL], 200 with relapsed
AML, 125 with chronic phase chronic myelogenous leukemia [CML], 100 with accelerated phase
or blastic phase CML, 250 with hairy cell leukemia, and 125 with relapsed ALL or CLL) will
be accrued for this study within 5 years.
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