Leukemia Clinical Trial
Official title:
Proposed Study of CLL Samples
RATIONALE: Studying samples of cells in the laboratory from patients with cancer may help
identify biomarkers related to cancer. It may also help doctors learn how patients respond
to treatment.
PURPOSE: This laboratory study is analyzing samples of cells from patients with chronic
lymphocytic leukemia who were treated on clinical trial ECOG-2997.
OBJECTIVES:
- To analyze the expression of a variety of informative molecules using a unique
high-resolution flow cytometric immunophenotyping technology in samples from patients
with chronic lymphocytic leukemia enrolled in clinical trial ECOG-2997.
OUTLINE: Cell samples are analyzed for the following prognostic biomarkers: ZAP-70,
phospho-Syk, phospho-GSK-3β, phospho-Akt, phospho-ZAP-70, cyclin D1, cyclin D2, p21cip1,
phospho-ReIA, IkappaBα, Bax, Mcl-1, PTEN, phospho-Erk1/2, and phospho-MEK1/2. Biomarker
signals are amplified using enzymatic amplification staining to obtain high resolution
detection of cell-surface markers on leukemic cells. Biomarker expression levels are
measured using fluorescence activated cell sorting analysis. Relationships between clinical
outcomes, standard flow cytometric analysis, cytogenetic studies, and high resolution
immunophenotyping will also be assessed.
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