Leukemia Clinical Trial
Official title:
Molecular Mechanisms of NOTCH Induced Transformation in T-ALL
Verified date | May 2017 |
Source | Eastern Cooperative Oncology Group |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help
doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This laboratory study is looking at tissue samples from patients with T-cell acute
lymphoblastic leukemia.
Status | Completed |
Enrollment | 49 |
Est. completion date | July 30, 2009 |
Est. primary completion date | July 30, 2009 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 120 Years |
Eligibility |
DISEASE CHARACTERISTICS: - Confirmed diagnosis of T-cell acute lymphoblastic leukemia - Frozen lymphoblast samples available - NOTCH1-mutated or wild type sample available PATIENT CHARACTERISTICS: - Not specified PRIOR CONCURRENT THERAPY: - Not specified Exclusion Criteria: - Not applicable |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
ECOG-ACRIN Cancer Research Group | National Cancer Institute (NCI) |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Transcriptional signatures associated with NOTCH1 mutations in T-cell acute lymphoblastic leukemia (T-ALL) cells | Mutational analysis | 1 month | |
Primary | Global changes on gene expression resulting from inactivation of NOTCH signaling in T-ALL cells | Gene expression | 1 month |
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