Leukemia Clinical Trial
Official title:
S9031-S9126-S9333-S9500-A, Examination of the Prognostic Significance of AML-Specific and Age-Associated Genes in AML Patients
RATIONALE: Studying samples of bone marrow and blood in the laboratory from patients with
cancer may help doctors learn more about changes that occur in DNA and identify biomarkers
related to cancer.
PURPOSE: This research study is looking at bone marrow and blood samples from patients with
acute myeloid leukemia.
OBJECTIVES:
- To determine whether the expression of previously identified acute myeloid leukemia
(AML)-specific and age-associated genes have prognostic significance in adult patients
with AML.
- To examine, preliminarily, if AML-specific and age-associated expression changes occur
in the most primitive hematopoietic leukemia blasts (i.e., CD34+/38-).
- To examine, preliminarily, whether methylation or histone modification of the IRF8 CPG
island/promoter region is correlated with IRF8 gene expression in AML.
OUTLINE: This is a multicenter study.
Previously collected specimens of RNA from pre-treatment marrow or peripheral blood are
obtained from a repository of SWOG clinical trials (SWOG-S9031, SWOG-9126, SWOG-9333, and
SWOG-9500). Samples are analyzed for absolute expression levels of 23 selected genes and
relative expression levels of splice variants via quantitative RT/PCR and GeneScan assays
and linked to clinical and outcome data from the main SWOG database. Samples from a subset
of patients are analyzed to confirm aberrant expression of acute myeloid leukemia-specific
and age-associated genes in highly enriched population of leukemic blasts (CD34+/CD38- and
CD34+/CD38+). DNA samples are also analyzed for correlation of IRF8 gene expression with
methylation or histone modification of the IRF8 CPG island/promoter region.
;
Time Perspective: Retrospective
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