Leukemia Clinical Trial
Official title:
Identification of Target Genes for Diagnosis and Prognosis of AML Using a Custom-Design Microarray
RATIONALE: Studying samples of blood and bone marrow in the laboratory from patients with
cancer may help doctors learn more about changes that occur in DNA and identify genes
related to cancer. It may also help doctors diagnose cancer and predict how patients will
respond to treatment.
PURPOSE: This research study is identifying cancer-related genes in blood and/or bone marrow
samples from patients with acute myeloid leukemia.
OBJECTIVES:
- To identify and validate individual genes for diagnosis of three major translocations
in acute myeloid leukemia.
- To correlate transcript expression data in the various translocations with age, sex,
race, response to treatment, and survival and with other known mutations.
OUTLINE: Blood and/or bone marrow samples previously procured from patients on CALGB-9665
are obtained from the CALGB Leukemia Tissue Bank from patients enrolled on CALGB AML
treatment studies. Mononuclear cells are isolated from samples and mRNA is extracted. Gene
expression profiles are analyzed via custom mRNA microarray and confirmed by quantitative
real-time PCR.
;
Observational Model: Cohort, Time Perspective: Retrospective
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