Bortezomib in Treating Patients With Advanced Myeloproliferative Disorders

Leukemia Clinical Trial

Official title:

A Prospective Open-Label Pilot Trial of PS-341 (Bortezomib; VELCADE) for the Therapy of Symptomatic Advanced Myeloproliferative Disorders

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00437086
• Other study ID #: CDR0000529906
• Secondary ID: P30CA015083MC048
• Status: Completed
• Phase: Phase 0
• First received: February 15, 2007
• Last updated: October 15, 2014
• Start date: September 2005
• Est. completion date: November 2008

Study information

• Verified date: October 2014
• Source: Mayo Clinic
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Food and Drug Administration
• Study type: Interventional

Clinical Trial Summary

RATIONALE: Bortezomib may stop the growth of abnormal cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the abnormal cells.

PURPOSE: This clinical trial is studying the side effects and how well bortezomib works in treating patients with advanced myeloproliferative disorders.

Description:

OBJECTIVES:

Primary

• Determine the efficacy of bortezomib in patients with symptomatic advanced myeloproliferative disorders (i.e., myelofibrosis with myeloid metaplasia, chronic myelomonocytic leukemia, or FIP1LI-PDGFRA-negative mast cell disease).

• Determine the safety of this drug when administered on a modified schedule in these patients.

Secondary

• Determine the effect of this drug on bone marrow cellularity, tryptase-positive mast cells, reticulin fibrosis, osteosclerosis, and angiogenesis in responding patients

OUTLINE: This is a prospective, open-label, pilot, multicenter study. Patients are stratified according to disease (systemic mast cell disease vs chronic myelomonocytic leukemia vs myelofibrosis with myeloid metaplasia).

Patients receive bortezomib IV weekly for 4 weeks. Treatment repeats every 5 weeks for up to 2 courses in the absence of disease progression or unacceptable toxicity. Patients achieving a response (complete remission, partial remission, or minimal remission) after 2 courses may receive an additional 6 courses of therapy. Patients who achieve stable disease with acceptable toxicities after 2 courses receive bortezomib IV at a higher dose twice weekly for 2 weeks. Treatment with a higher dose of bortezomib repeats every 3 weeks for up to 6 courses.

Patients who are responders undergo bone marrow aspirate or biopsy and peripheral blood collection for evaluation of bone marrow cellularity, tryptase-positive mast cells, reticulin fibrosis, osteosclerosis, and angiogenesis by fluorescent in situ hybridization (FISH), immunohistochemistry, and other immunological laboratory methods.

After completion of study therapy, patients are followed periodically for up to 3 years.

PROJECTED ACCRUAL: A total of 30 patients will be accrued for this study.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: November 2008
• Est. primary completion date: November 2008
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

DISEASE CHARACTERISTICS:

• Histologically confirmed advanced myeloproliferative disorder, including 1 of the following subtypes:

• Myelofibrosis with myeloid metaplasia defined by the following criteria:

• Evaluable or symptomatic disease as evidenced by = 1 of the following:

• Anemia, defined as hemoglobin < 10 g/dL OR erythrocyte-transfusion dependence, defined as requiring 1 transfusion within the past 8 weeks

• Symptomatic palpable splenomegaly (palpable hepatomegaly is acceptable if previously splenectomized) requiring treatment* NOTE: *Subjective but painful enough to mandate intervention

• Chronic myelomonocytic leukemia (CMML) defined by the following criteria:

• Absence of an imatinib mesylate-sensitive molecular abnormality for CMML (i.e., t[5;12], t[5;10], t[1;5], and t[5;7]) confirmed by fluorescent in situ hybridization (FISH) or standard cytogenetic bone marrow analysis within the past 18 months

• Symptomatic disease as evidenced by = 1 of the following:

• Anemia, defined as hemoglobin < 10 g/dL OR erythrocyte-transfusion dependence, defined as requiring 1 transfusion within the past 8 weeks

• Palpable splenomegaly (palpable hepatomegaly is acceptable if previously splenectomized) requiring treatment* NOTE: *Subjective but painful enough to mandate intervention

• Leukocytosis associated with ascites, serositis, pleural effusions, vasculitis, or other overt manifestation

• Systemic mast cell disease defined by the following criteria:

• Absence of the FIP1LI-PDGFRA mutation as confirmed by FISH

• Evaluable and symptomatic disease requiring therapy, as evidenced by involvement with organs other than skin (i.e., heart, bowel, peripheral blood, liver/spleen, or marrow)

• Debilitating mast cell mediator symptoms not responsive to standard therapy such as antihistamines

• Absence of t(9;22) translocation as confirmed by FISH or standard cytogenetic peripheral blood or marrow analysis at any prior time point

PATIENT CHARACTERISTICS:

• ECOG performance status 0-2

• Not pregnant or nursing

• Negative pregnancy test

• Fertile patients must use effective contraception

• Not incarcerated in a municipal, county, state, or federal prison

• Absolute neutrophil count = 1,000/mm³

• Platelet count = 75,000/mm³

• Creatinine = 2.0 mg/dL

• Total or direct bilirubin = 2.0 mg/dL

• AST and ALT = 3 times upper limit of normal (unless clinically attributed to hepatic extramedullary hematopoiesis)

• No baseline peripheral or autonomic neuropathy = grade 2

• No other condition or laboratory abnormality that would place the patient at unacceptable risk or confound the ability to interpret study data

• No hypersensitivity to boron, mannitol, or bortezomib

• No myocardial infarction within the past 6 months

• No New York Hospital Association class III-IV heart failure

• No uncontrolled angina

• No severe uncontrolled ventricular arrhythmia

• No evidence of acute ischemia or active conduction system abnormality by ECG

• ECG screening abnormalities must be documented as not medically relevant

• No other serious medical or psychiatric illness that would preclude study participation

PRIOR CONCURRENT THERAPY:

• At least 14 days since prior chemotherapy (e.g., interferon alfa, anagrelide, or other myelosuppressive agent) or any other experimental therapy

• At least 14 days since prior growth factors

• At least 14 days since prior systemic use of corticosteroids

• More than 14 days since prior investigational drugs

• Concurrent hydroxyurea allowed for = 14 days during study therapy if clinically indicated for extreme leukocytosis control

Study Design

Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Chronic Myeloproliferative Disorders
• Leukemia
• Myeloproliferative Disorders

Intervention

Drug:
• PS-341
1.6 mg/m2 by IV; 4 out of 5 weeks

Locations

Country	Name	City	State
United States	M. D. Anderson Cancer Center at University of Texas	Houston	Texas
United States	Mayo Clinic in Florida	Jacksonville	Florida
United States	Mayo Clinic	Rochester	Minnesota

Sponsors (2)

Lead Sponsor	Collaborator
Mayo Clinic	National Cancer Institute (NCI)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Number and severity of toxicities as assessed by NCI CTCAE v3.0		40 weeks	Yes
Primary	Proportion of patients who show treatment success, as defined by anemia, spleen, bone marrow, or constitutional symptoms' response (complete, partial, major, or minor response)		40 weeks	No
Secondary	Effects of treatment, in terms of changes in bone marrow cellularity, tryptase-positive mast cells, reticulin fibrosis, osteosclerosis, and angiogenesis, in responding patients		40 weeks	No