Leukemia Clinical Trial
Official title:
Chronic Myeloid Leukemia (CML) Cohort
RATIONALE: Gathering information about patients with chronic myelogenous leukemia may help
doctors learn more about the disease and find better methods of treatment and on-going care.
PURPOSE: This natural history study is collecting health information and disease-related
information over time from patients with newly diagnosed chronic myelogenous leukemia.
OBJECTIVES:
- Determine the impact of current procedures for diagnosis, management, and follow-up on
disease status of patients with newly diagnosed chronic myelogenous leukemia (CML).
- Determine the natural history of patients with CML who achieve response to imatinib
mesylate.
- Determine the health perceptions, symptoms, insurance issues, and work issues of these
patients.
- Determine whether medication compliance and planned dose reduction affect imatinib
mesylate effectiveness in these patients.
- Determine the molecular and biologic factors associated with disease progression and
good and poor response to imatinib mesylate in these patients.
OUTLINE: This is a longitudinal, prospective, cohort study.
Patients complete quality of life, functional status, medical and treatment history, and
medication questionnaires at baseline and then every 6 months for 5 years.
Blood samples are collected at baseline and then every 6 months for 5 years. Specimens may
be examined in the future in gene array studies and mutation analyses.
;
Observational Model: Cohort, Time Perspective: Prospective
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