Vaccine Therapy in Treating Patients With Acute Lymphoblastic Leukemia

Status Terminated

Clinical Trial Summary

The prognosis for children and adults with acute lymphoblastic leukemia (ALL) has improved significantly over the years. Nevertheless, patients who experience disease relapse or induction failure along with patients having unfavorable genetics [t(4;11) or t(9;22)] have dismal prognosis. For these patients, novel therapeutic approaches such as immunotherapy are needed. In this clinical trial, investigators evaluate whether it is feasible to make a vaccine from leukemia cells and whether this vaccine enables direct immunity against cancer cells in patients.

Clinical Trial Description

OBJECTIVES Primary

- To determine feasibility of generating a cellular vaccine composed of CD40-activated autologous ALL cells

- To determine feasibility of vaccine administration according to the proposed schedule

- To determine toxicity of vaccination with CD40-activated autologous ALL cells

Secondary

- To assess ALL-specific immunity following vaccination

- To assess the generation of immunity to control antigens

- To develop preliminary information on effect vaccination on tumor response ;

Study Design

Related Conditions & MeSH terms

Leukemia
Leukemia, Lymphoid
Precursor Cell Lymphoblastic Leukemia-Lymphoma

Clinical Trial Details

NCT number	NCT00020670
Study type	Interventional
Source	Dana-Farber Cancer Institute
Contact
Status	Terminated
Phase	Early Phase 1
Start date	February 20, 2001
Completion date	July 1, 2003

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