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Leukemia clinical trials

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NCT ID: NCT06247540 Withdrawn - Richter Syndrome Clinical Trials

Venetoclax, Rituximab and Nivolumab in Combination for the Treatment of Richter's Transformation Arising From Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Start date: March 29, 2024
Phase: Phase 2
Study type: Interventional

This phase II trial tests how well venetoclax, rituximab and nivolumab works in treating patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) with Richter's transformation. Richter's transformation can be described as the development of an aggressive lymphoma in the setting of underlying CLL/SLL that has a very poor prognosis with conventional therapies and represents a significant unmet medical need. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking BCL-2, a protein needed for cancer cell survival. Immunotherapy with monoclonal antibodies, such as rituximab and nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of cancer cells to grow and spread. Giving venetoclax, rituximab and nivolumab together may work better than the conventional intensive immunochemotherapy to improve disease control in patients with Richter's transformation arising from CLL/SLL.

NCT ID: NCT06180863 Withdrawn - Clinical trials for Acute Myeloid Leukemia

Oral Azacitidine (CC-486) Epigenetic Priming and Maintenance for Adult Acute Myeloid Leukemia (AML) Patients

Start date: November 2023
Phase: Phase 2
Study type: Interventional

To investigate the feasibility of delivering oral azacitidine (CC-486) as a consolidation regimen from the time of first complete remission (CR1), in patients with acute myelogenous leukemia (AML) eligible for curative intent Allogeneic Stem Cell Transplant (ASCT).

NCT ID: NCT06085638 Withdrawn - Clinical trials for Chronic Myelomonocytic Leukemia

Phase I/II Study of SY-1425 (Tamibarotene) in Combination With Azacitidine and Venetoclax for Patients With Chronic Myelomonocytic Leukemia

Start date: September 14, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

To learn if adding venetoclax to the chemotherapy combination of tamibarotene and azacitidine is more effective than tamibarotene and azacitidine alone in treating higher-risk CMM

NCT ID: NCT05961696 Withdrawn - Clinical trials for Refractory B-cell Acute Lymphoblastic Leukemia

A Phase I Study of Mosunetuzumab for Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia

Start date: July 5, 2023
Phase: Phase 1
Study type: Interventional

To find a recommended dose of mosunetuzumab that can be given to patients with ALL.

NCT ID: NCT05943314 Withdrawn - Clinical trials for Acute Myeloid Leukemia

Clinical Study on Safety and Efficacy of Anti-CLL1 /+CD33 CAR T Cells in the Treatment of Acute Myeloid Leukemia

Start date: July 12, 2023
Phase: N/A
Study type: Interventional

This is a single-center, single-arm, open, intravenous drug administration of the safety and efficacy of clinical study.

NCT ID: NCT05720988 Withdrawn - Clinical trials for Acute Myeloid Leukemia

Tagraxofusp to Eradicate Measurable Residual Disease in Patients With Acute Myeloid Leukemia

Start date: August 3, 2024
Phase: Phase 1
Study type: Interventional

This phase Ib/II trial tests the safety of tagraxofusp when given with or without azacitidine in patients with acute myeloid leukemia in remission with measurable residual disease who will undergo allogeneic hematopoietic cell transplant. Tagraxofusp is a recombinant protein consisting of IL-3 conjugated to a truncated diptheria toxin. The IL-3 attaches to the cancer cells and the toxic substance kills them. Azacitidine may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Tagraxofusp and azacitidine may work better to kill cancer cells and eradicate measurable residual disease in patients with acute myeloid leukemia.

NCT ID: NCT05622591 Withdrawn - Clinical trials for Acute Myeloid Leukemia

ELU001 in Pediatric Subjects Who Have Relapsed and/or Refractory CBFA2T3-GLIS2-positive AML

Pediatric AML
Start date: March 2024
Phase: Phase 1
Study type: Interventional

This research study was planned to focus on a rare type of acute myeloid leukemia (with the subtype CBFA2T3::GLIS2 that overexpresses folate receptor alpha (FRĪ±) (a protein on the surface of leukemia cells)) that has relapsed or is refractory. Relapse means the cancer has come back after treatment. Refractory means the cancer does not respond to treatment.

NCT ID: NCT05613348 Withdrawn - Clinical trials for B-cell Acute Lymphoblastic Leukemia

CD19 CAR T-cell Target Relapsed/Refractory Acute B Cell Leukemia/Lymphoma

CAR19T2
Start date: December 1, 2022
Phase: Phase 1/Phase 2
Study type: Interventional

This study aims to evaluate the safety and efficacy of humanized Anti-CD19 Chimeric Antigen Receptor-T cell (CAR19T2 T cell) in children with refractory/relapsed B-cell acute lymphoblastic leukemia/lymphoma.

NCT ID: NCT05595135 Withdrawn - Clinical trials for Acute Myeloid Leukemia

Mobile Intervention to Improve Adherence of Oral Anti-cancer Medications Among Acute Myeloid Leukemia Patients, the txt4AML Study

Start date: August 15, 2022
Phase: N/A
Study type: Interventional

This clinical trial studies how well a mobile intervention consisting of a text messaging program and an electronic "smart" pill bottle with medication reminders works to improve adherence to oral anti-cancer medications among patients with acute myeloid leukemia (AML). Medication adherence is how well patients take medications as prescribed by their doctors, and good medical adherence is when patients take medications correctly. Poor medication adherence has been shown to be a barrier to effective treatment. Collecting feedback on patient experiences using the mobile intervention may help doctors design new methods and material for providing educational information to AML patients who are taking oral anti-cancer medications.

NCT ID: NCT05571540 Withdrawn - Clinical trials for B-cell Acute Lymphoblastic Leukemia

Anti-CD19 Universal CAR-T Cells for r/r CD19+ B-ALL

Start date: October 1, 2022
Phase: Phase 1/Phase 2
Study type: Interventional

This is a single-arm, single-center, open-labeled clinical study to evaluate the safety and efficacy of LstCAR019 injection for patients with relapsed/refractory(r/r) B-cell Acute Lymphoblastic Leukemia(B-ALL).