Trial of Pimasertib in Hematological Malignancies

Status Terminated

Clinical Trial Summary

This is an open-label, multi-center, dose-escalation trial of pimasertib in blood and bone marrow cancers. The trial will be conducted in two parts:

Part 1 (safety run-in period): Will determine the maximum tolerated dose (MTD) of the study drug in subjects with advanced hematological malignancies.

Part 2: Will assess the anti-leukemic activity of the study drug in older subjects with newly diagnosed poor prognosis Acute Myeloid Leukemia (AML) who are not candidates for intensive chemotherapy.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00957580
Study type	Interventional
Source	EMD Serono
Contact
Status	Terminated
Phase	Phase 2
Start date	September 2009
Completion date	December 2012

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05319587` - Study of Liposomal Annamycin in Combination With Cytarabine for the Treatment of Subjects With Acute Myeloid Leukemia (AML)	Phase 1/Phase 2
Active, not recruiting	`NCT04090736` - Study to Compare Azacitidine Plus Pevonedistat Versus Azacitidine in Patients With Acute Myeloid Leukemia Not Eligible for Standard Chemotherapy	Phase 3
Completed	`NCT01617226` - Randomised Study of Azacitidine Versus Azacitidine With Vorinostat in Patients With AML or High Risk MDS	Phase 2
Terminated	`NCT00916045` - Pilot Study of Unrelated Cord Blood Transplantation	Phase 2
Completed	`NCT00640796` - Pilot Study of Expanded, Donor Natural Killer Cell Infusions for Refractory Non-B Lineage Hematologic Malignancies and Solid Tumors	Phase 1
Completed	`NCT00458250` - Feasibility of Haploidentical Hematopoietic Stem Cell Transplantation Using CAMPATH-1H	Phase 1
Active, not recruiting	`NCT05424380` - A Phase 1, Open Label Study of Intravenous GSK3745417 to Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Determine RP2D & Schedule in Participants With Relapsed or Refractory Myeloid Malignancies Including AML and HR MDS	Phase 1
Completed	`NCT01690624` - BI 836858 Dose Escalation in Patients With Refractory or Relapsed Acute Myeloid Leukemia and in Patients in Complete Remission With High Risk to Relapse	Phase 1
Recruiting	`NCT05471700` - Single Arm Study of Azacitidine and Venetoclax for Treatment of Newly Diagnosed Fit Acute Myeloid Leukemia Patients	Phase 1/Phase 2
Not yet recruiting	`NCT05016063` - Dual CD33-CLL1-CAR-T Cells in the Treatment of Relapsed/Refractory Acute Myeloid Leukemia	Early Phase 1
Not yet recruiting	`NCT04450784` - ObServatory Children Acute RElated Therapy Leukemia
Recruiting	`NCT04265963` - CD123-Targeted CAR-T Cell Therapy for Relapsed/Refractory Acute Myeloid Leukemia	Phase 1/Phase 2
Terminated	`NCT04968860` - Oral Health Condition and Quality of Life in Children With Leukemia
Recruiting	`NCT03793517` - Decitabine Plus mBU/CY for High Risk Acute Leukemia With MRD Pre-HSCT	Phase 2/Phase 3
Terminated	`NCT02841540` - A Study of H3B-8800 (RVT-2001) in Participants With Lower Risk Myelodysplastic Syndromes	Phase 1
Recruiting	`NCT05453903` - A Study of JNJ-75276617 in Combination With Acute Myeloid Leukemia (AML) Directed Therapies	Phase 1
Completed	`NCT03720366` - A Study of Perpetrator Drug Interactions of Enasidenib in AML Patients	Phase 1
Withdrawn	`NCT04230564` - Acute Myeloid Leukemia Real World Treatment Patterns
Terminated	`NCT03761069` - Study of PTC299 (Emvododstat) in Relapsed/Refractory Acute Leukemias	Phase 1
Completed	`NCT01835587` - Safety Study of Oral Azacitidine (CC-486) as Maintenance Therapy After Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) in Participants With Acute Myeloid Leukemia (AML) or Myelodysplastic Syndromes (MDS).	Phase 1/Phase 2