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"Geriatric Assessment Adapted" Therapy for Ph- ALL Elderly Patients — LAL1104  

Leukemia, Lymphoblastic, Acute Clinical Trial

Official title:
"Geriatric Assessment Adapted" Therapy for Ph- ALL Elderly Patients. GIMEMA Protocol LAL1104. EudraCT Code 2005-002156-17

Clinical Trial Summary

This study aims at considering clinical heterogeneity of patients based on a "geriatric assessment" without taking into account the real age of the subject. This will allow physicians to adapt therapy according to three different groups of patients: frail, fit and intermediate and to evaluate the efficacy and feasibility of a therapy adapted to the different categories of patients.

Clinical Trial Description

Treatment: 1. Frail patients: - Pretreatment with PDN - Induction with Vinblastine and PDN - Maintenance with MTX, 6-MP, VBL and PDN 2. Fit patients: - Pretreatment with PDN - Induction with VCR, DNR and PDN - Consolidation with MTX, ARA-C and G-CSF - Autologous transplantation - Maintenance with MTX, 6-MP, VCR, and PDN 3. Intermediate patients: - Pretreatment with PDN - Induction with VCR, DNR and PDN - Consolidation with MTX, ARA-C and G-CSF - A second cycle of consolidation therapy - Maintenance with MTX, 6-MP, VCR, and PDN ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00475280
Study type Interventional
Source Gruppo Italiano Malattie EMatologiche dell'Adulto
Contact
Status Completed
Phase Phase 2
Start date November 2007
Completion date January 28, 2020
View Details
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