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Leukemia, B-Cell, Chronic clinical trials

View clinical trials related to Leukemia, B-Cell, Chronic.

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NCT ID: NCT00559624 Completed - Clinical trials for Leukemia, B-Cell, Chronic

Safety and Tolerability Open Label Dose Escalation Study of Acadesine in B-CLL Patients

Start date: December 2007
Phase: Phase 1/Phase 2
Study type: Interventional

The main aim of this study is to test the safety of acadesine in patients with B-CLL and see what effects it has on patients and their leukaemia. The study also aims to examine the way acadesine is processed by the body. The study will look at the effects of acadesine in the body and the concentration of the drug and its main by-product (ZMP) in the blood to determine the dose and the frequency of dosing that is likely to be the most effective.

NCT ID: NCT00546793 Completed - Clinical trials for Lymphoma, Non-Hodgkin

Ph I/II Study of Subcutaneously Administered Veltuzumab (hA20) in NHL and CLL

Start date: January 2008
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to determine if a subcutaneous (SC) dosing schedule of veltuzumab can be established in NHL or CLL patients and to confirm the safety and efficacy of veltuzumab that was previously established when administered intravenously.

NCT ID: NCT00419250 Completed - Clinical trials for Chronic Lymphocytic Leukemia

A Dose Escalation Study of Lenalidomide in Relapsed or Refractory B-cell Chronic Lymphocytic Leukemia

Start date: December 1, 2006
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate the safety of lenalidomide and to define the maximum tolerated escalation dose level (MTEDL) when administered by a stepwise dose-escalation schedule in subjects with relapsed or refractory B-cell CLL.

NCT ID: NCT00344825 Completed - Clinical trials for Leukemia, B-Cell, Chronic

Vitalis Study - Observational Study on the Quality of Life in Patients Under Treatment for B-Chronic Lymphocytic Leukemia (B-CLL)

Start date: January 2004
Phase: N/A
Study type: Observational

300 patients, starting a new pharmacological treatment for B-CLL, were enrolled by 36 Italian Centres for assessing the Quality of Life (QoL). A descriptive analysis of QoL and the correlation of the age, sex, stage of disease, Time from first B-CLL diagnosis, Number of previous B-CLL treatments, reason of starting of the new B-CLL treatment: therapeutic Regimen, type of Centre, B-CLL treatment lasting, response to B-CLL treatment.

NCT ID: NCT00078520 Completed - Leukemia Clinical Trials

Treatment of B-CLL With Human IL-2 and CD40 Ligand and Plasmid Gene Modified Autologous Tumor Cells

CLIPA
Start date: January 2003
Phase: Phase 1
Study type: Interventional

This study is for patients that have chronic lymphocytic leukemia (CLL). This research study aims to determine the safety and dosage of special cells that may make the patients own immune system fight the cancer. To do this, we will put a special gene into cancer cells that have been taken from the patients body. This will be done in the laboratory. This gene will make the cells produce interleukin 2 (IL-2), which is a natural substance that may help the immune system kill cancer cells. Additionally, we will stimulate the cancer cells with another natural protein called CD40 ligand (CD40L), which experiments in animal and human cells in vitro demonstrated can help IL-2 perform better. Some of these cells will then be put back into the patient's body. Studies of cancers in animals and in cancer cells that are grown in laboratories suggest that combining substances like IL-2 and CD40L helps the body kill cancer cells. An experimental treatment similar to this has already been used in children and similar experimental treatments are being used in adults with other cancers.