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Clinical Trial Summary

Haploidentical hematopoietic stem cell transplantation irrespective of the conditioning and graft-versus-host disease prophylaxis is associated with high frequency of primary and secondary graft failure. Different technologies of with replete or depleted graft are associated with 10-20% of graft failures. Fludarabine and busulfan conditioning is the most commonly used approach for a variety of disease. Furthermore combination of fludarabine and bendamustine was sufficient to facilitate engraftment in patients with chronic lymphocytic leukemia and lymphomas. The aim of the study is to evaluate whether addition of bendamustine to fladarabine and busulfan conditioning reduces the risk of primary graft failure after haploidentical allograft.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04942730
Study type Interventional
Source St. Petersburg State Pavlov Medical University
Contact
Status Completed
Phase Phase 2
Start date January 21, 2021
Completion date April 30, 2024

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