Leprosy Clinical Trial
Official title:
Post ExpOsure Prophylaxis for LEprosy in the Comoros and Madagascar
This is a cluster randomized trial on effectiveness of different modalities of Single Double Dose of Rifampicin Post-Exposure Prophylaxis (SDDR-PEP) for leprosy in the Comoros (Anjouan and Mohéli) and Madagascar. The study aims to identify which approach to the selection of contacts for post exposure prophylaxis is most effective to reduce incident leprosy, and to Interrupt ongoing transmission from asymptomatic persons in the process of developing multibacillary leprosy.
For the purpose of the study, villages on the Comoros and Madagascar that will be randomly assigned to one of the study arms, will be screened on a yearly basis for 4 consecutive years. Depending on which of the 4 arms a village is assigned to, people in the surroundings of a leprosy patient will or will not be offered Post-Exposure Prophylaxis (PEP) using rifampicin at 20mg/kg single dose: 1. No Post-Exposure Prophylaxis (PEP) is given to anyone 2. PEP is given to all household contacts of incident leprosy cases 3. PEP is given to all people who live in a 100m radius of incident leprosy cases 4. PEP is given to all household contacts of incident leprosy cases as well as to all others who live within a 100m radius of an incident leprosy case and test positive in the UCP-LFA detecting anti-M. leprae PGL-I IgM antibodies (Ab) in fingerstick blood (anti-PGL-1) ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03302897 -
Phase 1 LEP-F1 + GLA-SE Vaccine Trial in Healthy Adult Volunteers
|
Phase 1 | |
Recruiting |
NCT05243654 -
Efficacy and Tolerability of Adjunct Metformin for Multibacillary Leprosy
|
Phase 2 | |
Completed |
NCT05091216 -
The Effects of Traditional Chinese Medicine Mouthwash Solutions on the Oral Health of Leprosy Patients
|
N/A | |
Completed |
NCT00860717 -
The Use of Low Level Laser Therapy for Wound Healing in Leprosy Patients
|
N/A | |
Recruiting |
NCT06222372 -
Novel Interventions and Diagnostic Tests for Leprosy
|
N/A | |
Terminated |
NCT03084614 -
CD8 Reactivity to Microorganisms in Blood and Breast Milk
|
||
Recruiting |
NCT05597280 -
Bedaquiline Enhanced Post ExpOsure Prophylaxis for Leprosy
|
Phase 3 | |
Terminated |
NCT01751503 -
Extramembranous and Interosseous Technique of Tibialis Posterior Tendon Transfer
|
N/A | |
Active, not recruiting |
NCT03324035 -
Treatment of Neuropathic Pain in Leprosy
|
Phase 3 | |
Completed |
NCT03683745 -
Integrated Mapping of Skin-presenting Neglected Tropical Diseases in Liberia
|
||
Recruiting |
NCT02550080 -
Clinical Utility Of Genetic Screening For HLA-B*1301, On Susceptibility To Dapsone Hypersensitivity Syndrome
|
Phase 4 | |
Completed |
NCT02484469 -
Impact of the Virtual Human Project on Team-based Learning: A Randomized-controlled Trial
|
N/A | |
Completed |
NCT00919542 -
Ciclosporin in the Management of New Erythema Nodosum Leprosum
|
Phase 2 | |
Completed |
NCT01165840 -
Effect of Weight and/or Obesity on Dapsone Drug Concentrations
|
Phase 4 | |
Completed |
NCT05406479 -
Bedaquiline Enhanced Post ExpOsure Prophylaxis for Leprosy (Phase 2)
|
Phase 2 | |
Recruiting |
NCT03807362 -
CC-11050 Trial in Nepalese Patients With Erythema Nodosum Leprosum
|
Phase 2 | |
Completed |
NCT01006759 -
Prevention of Disability: Proposal for a Guidance Manual for Leprosy Patients
|
Phase 1 | |
Completed |
NCT01920750 -
Leprosy Skin Test Antigens Phase 1
|
Phase 1 | |
Recruiting |
NCT06416033 -
Serum Irisin Level In Leprosy Patients
|
||
Not yet recruiting |
NCT03947437 -
Phase 1b/2a Trial to Evaluate LEP-F1 + GLA-SE in Healthy Adults and Leprosy Patients
|
Phase 1/Phase 2 |