Lentigo Maligna Clinical Trial
Official title:
Mohs Micrographic Surgery for Primary Cutaneous Malignant Melanoma In Situ Using Immunofluorescence
The purpose of this study is to determine if immunofluorescence (IF) can effectively identify features of malignant melanoma in situ, on sun-damaged skin, in the setting of Mohs Micrographic Surgery.
The aim of this study is to
1. Determine the feasibility of using melanocytic markers such as Melanoma antigen
recognized by T cells 1 (MART-1) with fluorescence to clear surgical margins when
compared to conventional MART-1 immunohistochemistry (IHC) in the setting of MMS for LM
(lentigo maligna type melanoma in situ).
2. Compare the use of a cocktail of immunofluorescent markers such as, but not limited to,
Sex-determining Region Y (SRY)-box 10 (SOX10), human melanoma black 45 (HMB-45), and
Kiel-67 (Ki-67) to sections only stained with fluorescent MART-1 alone.
3. Explore the value of using other combinations of immunofluorescent markers such as S-100
with Microphthalmia-associated transcription factor (MiTF), Nestin with Ki-67, and
HMB-45 with Lamin.
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