Preoperative Coadministration of Low-concentration Carbohydrate and Nitrates Loading vs Low- Concentration Carbohydrate Loading Alone in Patients Undergoing Open Gynecological Surgeries

Length of Hospital Stay Clinical Trial

Official title:
A Randomised Controlled Study of Preoperative Coadministration of Low-concentration Carbohydrate and Nitrates Loading vs Low- Concentration Carbohydrate Loading Alone in Patients Undergoing Open Gynecological Surgeries

Status Recruiting

Clinical Trial Summary

Surgery is known to be associated with stress response affecting in a negative way the clinical outcome and patient experience. The stress response includes both sympathetic nervous system activation and systemic inflammatory response. The pituitary- sympathetic one leads to a number of metabolic changes as hyperglycemia, nitrogen loss and lipolysis on the other hand the systemic inflammatory response aggravates the perioperative metabolic changes. One of components of ERAS is preoperative carbohydrate load. Oral carbohydrate was associated with attenuation of the postoperative metabolic stress response. Nitrate rich drinks before exercises have a promising impact due to improving blood flow, mitochondrial efficiency, glucose uptake and the sarcoplasmic calcium handling all of which maximize resistance to fatigue and improved exercise performance.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Length of Hospital Stay

Clinical Trial Details

NCT number	NCT04962776
Study type	Interventional
Source	Ain Shams University
Contact	Ibrahim Mamdouh Esmat
Phone	01001241928
Email	ibrahim_mamdouh@med.asu.edu.eg
Status	Recruiting
Phase	Phase 4
Start date	August 1, 2021
Completion date	September 30, 2024

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