Leishmaniasis Clinical Trial
Official title:
Transition-state Analog Inhibitor of Human Purine Nucleoside Phosphorylase as an Adjunct in Cutaneous Leishmaniasis Therapy: a Randomized and Controlled Trial
A clinical trial to asses efficacy and safety of Transition-state Analog Inhibitor of Human Purine Nucleoside Phosphorylase for topical use associated standard antimonial in the treatment of Cutaneous Leishmaniasis in Bahia, Brazil.
The treatment of cutaneous leishmaniasis caused by L. braziliensis in Brazil with pentavalent
antimony is associated with a high rate of failure, reaching up to 45% of cases.
Additionally, pentavalent antimony is only administered by parenteral route with important
toxicity and ulcer lesion healing takes a long time, from 2 to 3 months.
So, this randomized and controlled clinical trial was designed to compare the efficacy and
safety of standard antimonial (20mg/day /kg for 20 days) associated with Transition-state
Analog Inhibitor of Human Purine Nucleoside Phosphorylase for topical use versus standard
antimonial (20mg/kg/day for 20 days) associated with placebo for topical use in the treatment
of Cutaneous Leishmaniasis and Early Cutaneous Leishmaniasis caused by L. braziliensis in the
endemic area of Corte de Pedra, Bahia, Brazil.
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