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Clinical Trial Summary

The study aims to study the effect of simvastatin on the size of uterine fibroids.


Clinical Trial Description

The study is a phase II double blinded clinical trial to determine feasibility, safety and preliminary clinical efficacy of simvastatin to reduce leiomyoma size. Women with symptomatic fibroids planned to undergo surgical management for fibroids such as hysterectomy or myomectomy will be screened for participation. The eligible women will undergo pre-study evaluation to ascertain study eligibility.The study will enroll 60 participants in total, half will receive simvastatin and the other half will receive a placebo. The study drug and placebo will be an add on to the participants ongoing medical management of fibroids until surgery. The participants will be monitored at intervals for the effect of the drug on fibroid size and symptoms using ultrasound and quality of life questionnaires. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03400826
Study type Interventional
Source Johns Hopkins University
Contact Mostafa Borahay, MD, PhD
Phone (410) 550-0337
Email mboraha1@jhmi.edu
Status Recruiting
Phase Phase 2
Start date August 20, 2018
Completion date December 1, 2024

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