Legionnaires' Disease Clinical Trial
— LEGIOGREOfficial title:
Molecular Epidemiology of Legionellosis in Grenoble Region
The study aimed at further describing the epidemiological, clinical, diagnostic and prognostic features in legionellosis cases admitted to Grenoble University Hospital during the 2006-2011period. The investigators also tested lower respiratory samples collected from these patients during their routine medical care, using a number of molecular tools allowing determination of the involved Legionella species, the bacterial load, and the presence of antibiotic resistant mutants. Our primary goal was to define biological markers that could predict severity and outcome of infection in legionellosis cases requiring hospitalization.
Status | Completed |
Enrollment | 82 |
Est. completion date | December 2014 |
Est. primary completion date | December 2011 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years to 99 Years |
Eligibility |
Inclusion Criteria: - age higher than 18 years - proven legionellosis case (positive culture and/or PCR and/or urinary antigen test) - severe case requiring hospitalization Exclusion Criteria: - age under 18 years - pregnant women |
Observational Model: Cohort, Time Perspective: Retrospective
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Grenoble |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Legionella DNA load in lower respiratory tract samples | Real-time polymerase chain reaction (qPCR) dosages in lower respiratory tract samples collected on a routine basis all over the hospitalization duration | through study completion, an average of 1 year | No |
Secondary | Fluoroquinolones resistant gyrA mutants in lower respiratory tract samples | Real-time polymerase chain reaction (qPCR) and high-throughput DNA sequencing testing of lower respiratory tract samples collected on a routine basis all over the hospitalization duration | through study completion, an average of 1 year | No |
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