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Left Ventricular Noncompaction clinical trials

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NCT ID: NCT06024759 Recruiting - Clinical trials for Left Ventricular Noncompaction

Predictors of Risk in Left Ventricular Non-Compaction

Start date: September 1, 2023
Phase:
Study type: Observational [Patient Registry]

The goal of this study is to learn more about the risk factors associated with left ventricular non-compaction (LVNC) and the predictors of adverse outcomes associated with LVNC. The main questions this study aims to answer are as follows. - Are there any genetic mutations that impact the risk of LVNC patients developing ventricular arrhythmias? - Does LV myocardial strain increase risk stratification in the LVNC population with or without genetic mutations? - What are some of the determinants that cause LV dysfunction in LVNC? - What are other risk stratifiers (ex. premature ventricular contraction (PVC) burden on Holter, non-sustained ventricular tachycardia (NSVT) on stress test) that lead to an outcome of ICD implantation? Participants will have their medical records accessed annually for a span of ten years, either prospectively or retrospectively depending on whether they are being actively followed by physicians at the Inherited Arrhythmia Clinic or not, to evaluate LVNC progression over time. This data will be stored in a large clinical registry with the London Heart Rhythm Program at the London Health Sciences Centre, University Hospital Campus.

NCT ID: NCT03572569 Recruiting - Clinical trials for Hypertrophic Cardiomyopathy

Risk Stratification in Children and Adolescents With Primary Cardiomyopathy

RIKADA
Start date: January 2013
Phase:
Study type: Observational

RIKADA is a prospective study performing systematic family screening including clinical and genetic testing in pediatric patients with primary cardiomyopathy and their first-degree relatives with the aim to facilitate risk stratification.

NCT ID: NCT01470014 Completed - Clinical trials for Left Ventricular Noncompaction

Cardiac Computed Tomography: Characteristics of Isolated Left Ventricular Non-compaction

Start date: October 2011
Phase: N/A
Study type: Observational

The diagnostic criteria for isolated left ventricular non-compaction cardiomyopathy (IVNC) have been well established for echocardiography and cardiac magnetic resonance, such validation is lacking for computed tomography (CT). Such criteria are of great clinical relevance as a growing number of patients undergo a cardiac CT scan in daily clinical routine. The investigators aim to test the diagnostic accuracy of cardiac CT in distinguishing IVNC from lesser degrees of trabecular layering seen in potential differential diagnoses such as cardiomyopathies and left ventricular hypertrophy or dilation. The investigators hypothesize that echocardiographic diagnosed pathological trabeculation can be distinguished by determining the ratio of non-compacted to compacted myocardium on cardiac CT.