Clinical Trials Logo

Clinical Trial Summary

To evaluate the concept of dynamic pump speed optimization based on the echocardiographic assessment of aortic valve opening during cardiopulmonary exercise test.


Clinical Trial Description

Left ventricular assist devices (LVAD) are becoming a destination therapy in patients with end-stage left ventricular dysfunction. Current generation pumps operate with a fixed rotation speed without the capability of automated speed adjustment. It was shown that acceleration of the pump speed during stress test increases the maximum exercise tolerance. Periodic aortic valve opening (AVO) is used to set up an optimal resting pump speed. The study aimed to evaluate the concept of dynamic pump speed optimization based on the echocardiographic assessment of AVO during the cardiopulmonary exercise test (CPET). Patients with implanted third-generation LVADs with hydrodynamic bearing (HVAD, Medtronic, MN, USA) are prospectively enrolled. Two CPETs are performed after resting speed optimization. The first one with maintained baseline pump speed settings, and the second one with gradually increased speed depending on live echocardiographic imaging. The sequence of tests is random. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05063006
Study type Interventional
Source John Paul II Hospital, Krakow
Contact
Status Completed
Phase N/A
Start date February 15, 2017
Completion date August 4, 2020

See also
  Status Clinical Trial Phase
Withdrawn NCT03091998 - Subcu Administration of CD-NP in Heart Failure Patients With Left Ventricular Assist Device Support Phase 1
Recruiting NCT04377854 - Prognostic Value of BNP in MCS - a 25 Year Follow up Study
Terminated NCT03346278 - Text Message Intervention to Improve Cardiac Rehab Participation N/A
Completed NCT01477528 - Study of Reduced Anti-coagulation/Anti-platelet Therapy in Patients With the HeartMate II Left Ventricular Assist System (LVAS) (TRACE)
Completed NCT01485666 - Thoratec's Reduce Driveline Trauma Through Stabilization and Exit Site Management Study
Completed NCT03143569 - Ventricular Assist Device Anti-Factor Xa (VAD ANTIX) Monitoring Study: a Prospective Randomized Feasibility Trial N/A
Completed NCT03217331 - CRD-102 for Right Heart Failure in Patients With Left Ventricular Assist Devices Phase 1/Phase 2
Recruiting NCT03583970 - Veno-arterial Extracorporeal Membrane Oxygenation Prior to Left Ventricular Assist Device Implantation.
Withdrawn NCT05916612 - Influence of Right Ventricular Function on Changes in Exercise Capacity After LVAD
Recruiting NCT04205760 - Preoperative Nutritional Optimization and Physical Exercise for Patients Scheduled for Elective Implantation for a Left-Ventricular Assist Device Phase 3
Terminated NCT04264182 - STandardized Ultra-conservative Or Physician-directed ICD Programming for Continuous Flow LVAD Support N/A
Completed NCT03458988 - Blood-pressure Measuring in Patients Carrying a Left Ventricular Assist Device N/A
Withdrawn NCT01642927 - Pulse Wave Analysis in Advanced Heart Failure
Completed NCT03636815 - The Effect of Physical Therapy Intervention in Patients With Left Ventricular Assistive Device on Physical Function
Recruiting NCT04423562 - PROgnostic Value of Exercise Capacity Measured as Peak Oxygen Uptake (pVO2) in Recipients of Left Ventricular Assist Devices