Left Atrial Thrombosis Clinical Trial
Official title:
Detection of Left Atrial Thrombus by Cardiac Magnetic Resonance in Patients Undergoing Percutaneous Mitral Commissurotomy
The incidence of rheumatic heart diseases have not declined in our population .Rheumatic
heart diseases, often neglected by media and policy makers, is a major burden in developing
countries where it causes most of the cardiovascular morbidity and mortality in young people,
leading to about 250000 deaths per year worldwide. Mitralstenosis is one of the most common
complications of rheumatic heart diseases in our community. A treatment of choice in suitable
cases is percutaneous Mitral Commissurotomy .Preoperative evaluation for Percutaneous Mitral
Commissurotomy typically requires trans-esophageal echocardiogram (TEE) for the presence of
LA thrombus. TEE is currently considered the gold standard for LA thrombus detection given
its favorable sensitivity and specificity . With recent advances,CMRis now becoming another
reliable diagnostic method for evaluation of thrombus in the left atrium, particularly when
delayed imaging is performed.
Whereas TEE is a semi-invasive procedure, CMRis totally non-invasive . Effectiveness of left
ventricular thrombus detection by CMR has been validated, and it is now becoming a preferred
imaging modality for evaluation of left ventricular thrombus . Moreover, in patients
undergoing pulmonary vein isolation,Cardiac Magnetic Resonance was validated against TEE for
LA & left atrial appendage . To our knowledge, there are few data regarding the utility of
Cardiac Magnetic Resonance for detection of LA thrombus in patients undergoing Percutaneous
Mitral Commissurotomy.
Patients with Mitral stenosis that admitted in Assiut University hospital -Cardiovascular
Department for doing Percutaneous Mitral Commissurotomy Will undergo Trans-esophageal echo
and Cardiac Magnetic Resonance for detection of left atrial Thrombus and left atrial
appendage thrombus. Investigators will compare the result of Cardiac Magnetic Resonance with
the results of Trans-esophageal echo for seen the sensitivity and specificity of Cardiac
Magnetic Resonance in compare to Trans-esophageal echo who is the gold standard imaging for
detection of left atrial and left atrial appendage Thrombus.Data will be presented as mean ±
standard deviation for continuous variables and frequency for categorical variables.
- Patients with and without thrombus will be compared using independent (unpaired) Student
t test for continuous variables and the Fisher exact test for categorical variables, or
their non-parametric equivalents, after testing the data for normality.
- Diagnostic performance of each CMR component will be calculated in the standard manner.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
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Phase 4 | |
| Completed |
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