Lean Body Mass Clinical Trial
— MEMOOfficial title:
Does Muscle Mass at Intensive Care Unit Admission Determine Mortality: The Memo Study
Verified date | May 2023 |
Source | University Hospital, Geneva |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
This retrospective monocentric study aims to investigate whether a low muscle mass at ICU admission and its loss over the ICU stay predicts mortality, and in what proportion we can counteract it by nutritional support.
Status | Active, not recruiting |
Enrollment | 4000 |
Est. completion date | January 31, 2024 |
Est. primary completion date | December 31, 2022 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Associations of baseline body composition with clinical outcomes: Adults = 18 yrs, hospitalized in the ICU of the HUG between January 1st 2010 and December 31st 2022 and Abdominal, or thoraco-abdominal CT scan measured 48 hours before to 96 hours after ICU admission in the HUG - Associations of body composition changes with clinical outcomes, nutritional support or medico-economic paratemers: Identical as for the associations of baseline body composition with clinical outcomes and At least one additional CT performed during the hospital stay Exclusion Criteria: - Associations of baseline body composition with clinical outcomes: CT scans of low quality or CT scans performed outside of the HUG or Presence of a documented refusal - Associations of body composition changes with clinical outcomes, nutritional support or medico-economic paratemers: Additionnally: oral nutrition, because we cannot assess the quantity and composition of oral intakes retrospectively |
Country | Name | City | State |
---|---|---|---|
Switzerland | Laurence Genton | Geneva |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Geneva | VBertoniMaluf |
Switzerland,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | 30-day mortality | Association between skeletal muscle index (SMI) at the L3 vertebra level (psoas + abdominal wall muscles + paraspinal muscles), measured from 48 hours before to 96 hours after ICU admission, with 30-day mortality. | 30-day mortality between January 1st 2010 and December 31st 2022. | |
Secondary | Association of baseline body composition at ICU admission with other outcomes | Association of Skeletal muscle area (SMA), SMAH (Skeletal muscle area/height), SMD (Skeletal muscle density), IMAT (intermuscular and intramuscular adipose tissue), visceral and subcutaneous adipose tissue at the L3 vertebra level with 30-day mortality Determination of cut-off points of SMI, by sex, below which there is an increased risk of 30-day mortality Added value of body composition to ICU severity scores to predict 30-day mortality Association of baseline SMI, SMA, SMAH, SMD, intermuscular, visceral and subcutaneous adipose tissue at the L3 level, with ICU and hospital mortality and LOS, 30-day ICU readmission, duration of mechanical ventilation and infections | 30-day | |
Secondary | Association of baseline SMI at the L3 vertebra level vs. other locations to predict outcomes | Associations of SMI at the L3 vertebra level with SMI at the other locations Associations of SMI at the other locations with ICU and hospital mortality and LOS, 30-day ICU readmission, duration of mechanical ventilation and infections Comparison of the associations between muscle mass measured at the different anatomical locations and mortality in order to determine the best prognostic location | Day 1 to day 30 | |
Secondary | Association of body composition changes with outcomes | Association of changes in SMI, SMA, SMAH, SMD, IMAT, visceral and subcutaneous adipose tissue with 30-day mortality, ICU and hospital mortality and LOS, 30-day ICU readmission, duration of mechanical ventilation and infections Added value of changes in body composition to changes in ICU severity scores to predict 30-day mortality | Day 30 | |
Secondary | Association of body composition changes with nutritional support | Association of changes in energy coverage and changes in body composition Association of changes in protein coverage and changes in body composition | Day 30 | |
Secondary | Association of muscle loss with medico-economical parameters | Association of baseline muscle mass and muscle loss in the ICU with ICU and hospital costs Association of muscle loss in the ICU with level of nursing workload | Day 30 |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
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