Environmental Contaminants and Infant Development

Lead Poisoning Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00013858
• Other study ID #: 7902-CP-001
• Status: Completed
• Phase: N/A
• First received: March 30, 2001
• Last updated: April 13, 2015
• Start date: January 1997
• Est. completion date: August 2011

Study information

• Verified date: April 2015
• Source: National Institute of Environmental Health Sciences (NIEHS)
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Federal Government
• Study type: Observational

Clinical Trial Summary

This study is designed to examine the effects of prenatal exposure to environmental contaminants on cognitive and behavioral development and physical growth in two groups of Inuit infants-one in Northern Quebec; the other in Greenland.

Description:

Due to prevailing weather patterns and ocean currents, certain environmental contaminants are transported to the Arctic region. The Inuit are among the most heavily exposed populations on earth due to the prevalence of these contaminants in traditional foods that comprise a large portion of their diet. The contaminants assessed in this study include polychlorinated biphenyls (PCBs), methylmercury, selenium, organochlorine pesticides, and lead. These contaminants are measured in umbilical cord blood samples obtained at birth, milk samples obtained from breast-feeding mothers and, in the case of mercury, hair samples obtained from the mothers. Omega-3 and omega-6 fatty acids are also assessed in these samples to examine the degree to which these nutrients may protect against adverse effects attributable to these contaminants.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 280
• Est. completion date: August 2011
• Est. primary completion date: August 2011
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: N/A to 1 Day

Eligibility

infant born during recruitment period to a mother who is a resident of Povungnituk, Inukjuak, and Kuujjuarapik, Quebec or Nuuk, Greenland

Study Design

Time Perspective: Prospective

Related Conditions & MeSH terms

• Lead Poisoning
• Mercury Poisoning
• Poisoning

Locations

Country	Name	City	State
Canada	Public Health Centre of Quebec	Beauport	Quebec

Sponsors (4)

Lead Sponsor	Collaborator
National Institute of Environmental Health Sciences (NIEHS)	Danish Institute for Public Health, Health Canada, Indian and Northern Affairs, Canada

Country where clinical trial is conducted

Canada, 

References & Publications (4)

Dewailly E, Ayotte P, Bruneau S, Laliberté C, Muir DC, Norstrom RJ. Inuit exposure to organochlorines through the aquatic food chain in arctic québec. Environ Health Perspect. 1993 Dec;101(7):618-20. — View Citation

Dewailly, E., Bruneau, S., Ayotte, P., Liliberte, C., Gingras, S. Belander, D. and Ferron, L. Health status at birth of Inuit newborn prenatally exposed to organochlorines - Chemosphre, 1993, 27: 359-366.

Jacobson JL, Jacobson SW. Intellectual impairment in children exposed to polychlorinated biphenyls in utero. N Engl J Med. 1996 Sep 12;335(11):783-9. — View Citation

Jacobson SW, Fein GG, Jacobson JL, Schwartz PM, Dowler JK. The effect of intrauterine PCB exposure on visual recognition memory. Child Dev. 1985 Aug;56(4):853-60. — View Citation