Lead Poisoning Clinical Trial
OBJECTIVES:
Compare growth of lead-poisoned children receiving succimer (dimercaptosuccinic acid; DMSA)
plus standard treatment to those receiving standard treatment only.
PROTOCOL OUTLINE: This is randomized study. Patients are randomized to receive succimer in
addition to standard treatment (arm I) or standard treatment only (arm II).
Succimer is administered orally 3 times a day for 7 days, then twice daily for 19 days.
Patients may receive up to 3 courses.
Standard treatment consists of a medical history and physical examination, environmental
assessment with modification to reduce lead exposure, dietary modifications to decrease lead
absorption, the use of a daily multivitamin and mineral supplement with iron, developmental
screening and intervention, and frequent follow up of lead levels.
If blood lead level rises above 45 mcg/dL, patient receives succimer regardless of treatment
arm originally assigned.
Patients are followed every 3-4 weeks for 2 months, then every 3 months for 6 months, and
then every 6 months thereafter.
;
Allocation: Randomized, Primary Purpose: Treatment
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