LDL Cholesterol Clinical Trial
Official title:
Effect of Viscous Soluble Fibers on Serum Cholesterol Levels: A Series of Systematic Reviews and Meta-analyses
Research over the past several decades have linked the intake of dietary fiber with lower
blood cholesterol levels. The distinction between soluble and insoluble fiber fractions
emerged shortly after and there is now a general consensus that soluble fiber possesses the
capacity to lower cholesterol. Since the discovery of the cholesterol lowering effects of
soluble dietary fiber, there has been much debate as to the degree of cholesterol reduction
from these fibers. In order to handle the inconsistencies a full and systematic review of
the published literature was conducted by Brown et. al (1999). Results from this
meta-analysis, concluded that 'increasing soluble fiber can make only a small contribution
to lowering cholesterol.'
Research is constantly progressing and new research findings may not always be consistent
with older data. For example, results from new research are now challenging the previously
approved health claims for soy foods and fatty acids. This is a major public health concern
because if clinical evidence is not reliable, it could lead to harm. Since the publication
of the meta-analysis by Brown et. al (1999) over a decade ago, scientists have continued to
research the effects of soluble fiber on cholesterol levels with new technology and trial
designs, therefore it is crucial to revisit the question and update the literature on the
effect of viscous soluble dietary fibers on serum cholesterol levels.
A series of meta-analyses will be performed to assess the link between viscous dietary
fibers and serum cholesterol levels. Nutritionists now consider fiber to be an integral part
of diet and disease. Results from these meta-analyses help address the question of whether
viscous soluble fibers have a role lowering serum cholesterol levels.
n/a
Time Perspective: Retrospective
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