View clinical trials related to Lassa Virus Infection.
Filter by:This is a randomized, placebo-controlled, single-center, dose finding phase I trial in healthy adult volunteer participants consisting of two phases, an unblinded dose escalation and an observer-blinded treatment phase. The aim is to investigate the safety, tolerability and immunogenicity of MV-LASV after administration of two different dose levels of MV-LASV. Placebo will be applied to blind the different Treatment schedules.
Background: - Lassa fever is very similar to other diseases that cause fever, such as malaria and yellow fever. People get Lassa fever from mice. A person can get Lassa fever from mice urine and droppings. When a group of researchers tested the mice in Soromba, Mali, they found that many were infected with Lassa fever. Lassa fever may also be passed through body fluids (like blood or semen) of people infected with Lassa fever. Researchers want to study this disease to help the government better protect the health of people in Sibirila. Objectives: - To find out how many people in Sibirila have ever had Lassa fever. Also, to measure how many people get the disease every year. Eligibility: - People age 6 months and older who are residents of Soromba, Bamba, or Banzana with no plans to relocate within 1 year. Design: - Households will be randomly selected to participate in the study. - Participants will have up to 20 drops of blood collected from the finger or heel. - Participants will be asked about their age. They will be asked if they have ever had a fever and if they have ever seen mice in or around their home. - Researchers will come back in 1 year and take another drop of blood from the participant. Participants will be asked the same questions. - If a participant has a fever at any time during the year, he or she should go to the health center. Researchers will collect a few drops of blood to test for Lassa fever. ...