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Clinical Trial Details — Status: Terminated

Administrative data

NCT number NCT01445847
Other study ID # E-11-491
Secondary ID
Status Terminated
Phase N/A
First received September 29, 2011
Last updated January 1, 2015
Start date January 2012
Est. completion date April 2012

Study information

Verified date January 2015
Source King Saud University
Contact n/a
Is FDA regulated No
Health authority Saudi Arabia: Ministry for Higher Education
Study type Interventional

Clinical Trial Summary

In the literature, we found no randomized clinical trials addressing the using of IV lidocaine as prophylaxis for postoperative laryngospasm among adults.

The aim of this study was to assess the effects of IV lidocaine on the incidence of postoperative laryngospasm of adults patients.


Description:

During anesthesia practice, one of the common complications of airway management is laryngospasm. The etiology of laryngospasm is unknown but may be due to insufficient depth of anesthesia during tracheal intubation, light plane of anesthesia during tracheal extubation, pain, or presence of airway irritant like laryngoscope blade, irritated volatile agent, suction catheter, surgical debris, mucus, blood, or other foreign body. Laryngospasm occurs in both genders and all ages. Incidence of laryngospasm was reported to the Australian incident monitoring study (AIMS) was 5% with of 22% of them without an attributable cause.

Currently, there is no proven prophylaxis for laryngospasm and the known treatments of laryngospasm are used post-occurrence. However, elimination of factors that lead to laryngospasm is the most indispensable item for reduction of its incidence.

Intravenous (IV) lidocaine interrupts nerve conduction by blocking sodium channels. Recent meta-analysis study showed that IV lidocaine was able to prevent laryngospasm in children. However, in the literature, we found no randomized clinical trials addressing the using of IV lidocaine as prophylaxis for postoperative laryngospasm among adults.

The aim of this study was to assess the effects of IV lidocaine on the incidence of postoperative laryngospasm of adults patients.


Recruitment information / eligibility

Status Terminated
Enrollment 400
Est. completion date April 2012
Est. primary completion date April 2012
Accepts healthy volunteers No
Gender Both
Age group 18 Years to 60 Years
Eligibility Inclusion Criteria:

- American Society of Anesthesia score are I or II

- Undergo for laparoscopic cholecystectomy

Exclusion Criteria:

- Patient's refusal

- History of upper respiratory tract infection (URTI) within 2 weeks

- Persistent type of hyper-reactive airway or asthma

- History of airway surgery

- History of gastro-esophageal reflex disease (GERD)

- Currently receiving sedating or analgesic medication

- Currently receiving the following medications:

- Fluvoxamine

- Erythromycin and Itraconazole

- ß -blocker or Cimetidine

- History of Lidocaine Allergy

- History of epilepsy disorder

- Pregnant or breastfeeding women

- History of Heavy Smoking ( a smoker with a daily cigarettes consumption of more than 20 pieces

- History of increased salivation by a disease or medication

- History of difficult intubation

- Two or more attempts of intubation

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention


Related Conditions & MeSH terms


Intervention

Drug:
Lidocaine
1 mg/kg or 1 mL/10 kg prior to extubation period. Injection of Lidocaine will be immediately when inhalational agent (Desflurane) is discontinued.
Other:
Placebo
1 mL/10 kg prior to extubation period. Injection of placebo will be immediately when inhalational agent (Desflurane) is discontinued.

Locations

Country Name City State
Saudi Arabia College of Medicine - King Saud University Medical City Riyadh

Sponsors (1)

Lead Sponsor Collaborator
King Saud University

Country where clinical trial is conducted

Saudi Arabia, 

Outcome

Type Measure Description Time frame Safety issue
Primary Number of Patients With Laryngospasm Postoperatively There were 4 scores of laryngospasm:
0 = No Laryngospasm
= Stridor or partial laryngospasm
= Complete Laryngospasm
= Cyanosis
within first 15 minutes post-dose Yes
See also
  Status Clinical Trial Phase
Completed NCT01222169 - Laryngeal Reflex Study Under Propofol Anesthesia: Effect of Intravenous Lidocaine Phase 3
Completed NCT04159116 - Prevention and Treatment of Laryngospasm and Hypoxemia Based on Risk Factors in Adult Outpatients Undergoing EGD N/A
Active, not recruiting NCT01288248 - Noninferiority Clinical Trial With Laryngeal Mask and Endotracheal Tube Phase 3
Terminated NCT00665418 - Sevoflurane and Laryngeal Reflex Responses in Pediatric Patients Phase 4
Completed NCT00925613 - Benefits of Exchanging a Double Lumen Tube to a Proseal Laryngeal Mask or a Single Lumen Tube After a Thoracic Surgery Phase 3