Laryngospasm Clinical Trial
Official title:
Effect of Intravenous Lidocaine on the Incidence of Post-extubation Laryngospasm: A Randomised Controlled Trial
Verified date | January 2015 |
Source | King Saud University |
Contact | n/a |
Is FDA regulated | No |
Health authority | Saudi Arabia: Ministry for Higher Education |
Study type | Interventional |
In the literature, we found no randomized clinical trials addressing the using of IV
lidocaine as prophylaxis for postoperative laryngospasm among adults.
The aim of this study was to assess the effects of IV lidocaine on the incidence of
postoperative laryngospasm of adults patients.
Status | Terminated |
Enrollment | 400 |
Est. completion date | April 2012 |
Est. primary completion date | April 2012 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years to 60 Years |
Eligibility |
Inclusion Criteria: - American Society of Anesthesia score are I or II - Undergo for laparoscopic cholecystectomy Exclusion Criteria: - Patient's refusal - History of upper respiratory tract infection (URTI) within 2 weeks - Persistent type of hyper-reactive airway or asthma - History of airway surgery - History of gastro-esophageal reflex disease (GERD) - Currently receiving sedating or analgesic medication - Currently receiving the following medications: - Fluvoxamine - Erythromycin and Itraconazole - ß -blocker or Cimetidine - History of Lidocaine Allergy - History of epilepsy disorder - Pregnant or breastfeeding women - History of Heavy Smoking ( a smoker with a daily cigarettes consumption of more than 20 pieces - History of increased salivation by a disease or medication - History of difficult intubation - Two or more attempts of intubation |
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention
Country | Name | City | State |
---|---|---|---|
Saudi Arabia | College of Medicine - King Saud University Medical City | Riyadh |
Lead Sponsor | Collaborator |
---|---|
King Saud University |
Saudi Arabia,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Number of Patients With Laryngospasm Postoperatively | There were 4 scores of laryngospasm: 0 = No Laryngospasm = Stridor or partial laryngospasm = Complete Laryngospasm = Cyanosis |
within first 15 minutes post-dose | Yes |
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