Laryngospasm Clinical Trial
Official title:
Effect of Intravenous Lidocaine on the Incidence of Post-extubation Laryngospasm: A Randomised Controlled Trial
In the literature, we found no randomized clinical trials addressing the using of IV
lidocaine as prophylaxis for postoperative laryngospasm among adults.
The aim of this study was to assess the effects of IV lidocaine on the incidence of
postoperative laryngospasm of adults patients.
During anesthesia practice, one of the common complications of airway management is
laryngospasm. The etiology of laryngospasm is unknown but may be due to insufficient depth
of anesthesia during tracheal intubation, light plane of anesthesia during tracheal
extubation, pain, or presence of airway irritant like laryngoscope blade, irritated volatile
agent, suction catheter, surgical debris, mucus, blood, or other foreign body. Laryngospasm
occurs in both genders and all ages. Incidence of laryngospasm was reported to the
Australian incident monitoring study (AIMS) was 5% with of 22% of them without an
attributable cause.
Currently, there is no proven prophylaxis for laryngospasm and the known treatments of
laryngospasm are used post-occurrence. However, elimination of factors that lead to
laryngospasm is the most indispensable item for reduction of its incidence.
Intravenous (IV) lidocaine interrupts nerve conduction by blocking sodium channels. Recent
meta-analysis study showed that IV lidocaine was able to prevent laryngospasm in children.
However, in the literature, we found no randomized clinical trials addressing the using of
IV lidocaine as prophylaxis for postoperative laryngospasm among adults.
The aim of this study was to assess the effects of IV lidocaine on the incidence of
postoperative laryngospasm of adults patients.
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Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention
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