Laryngeal Carcinoma Clinical Trial
Official title:
Thulium Contact Laser in the Treatment of Tumorous and Non-tumorous Laryngotracheal Stenosis
The purpose of the study is to compare results of the treatment of tumorous and non-tumorous laryngotracheal stenosis using thulium contact laser versus carbon dioxide laser used in the past.
Laryngotracheal stenosis is a serious disease significantly worsening the quality of life.
Impaired breathing often leads to tracheotomy, deterioration of the voice leads to
communication problems with others and swallowing problems are often present, as well The
main causes of laryngotracheal stenosis are post intubation and post tracheostomy conditions,
inflammatory process (often autoimmune), tumors (mainly squamous cell carcinoma and
chondroma) and trauma. Within the last years there is substantial shift in the treatment
strategy from open surgery to endoscopic techniques. However, surgical treatment is often
difficult due to demanding exposure of tumor and problematic margins control.
In recent years there has been a development of particular techniques of endoscopic resection
of tumors and non-malignant laryngeal glottic and subglottic stenosis using a carbon dioxide
(CO2) laser with promising improvement of treatment results.
However, CO2 laser has some limitations, particularly in the treatment of tumors spreading
into anterior commissure, because CO2 laser beam cannot get "around the corner". Moreover,
subglottic area is also difficult to be reached by CO2 laser beam. Therefore, contact laser
with adjustable manipulators with possibility to bend tip of manipulator according to the
actual need seems to be of some advantage.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04788264 -
Exercise Training and Behavioral Modification for the Improvement of Physical Activity in Head and Neck Cancer Patients Undergoing Cancer Treatment
|
N/A | |
| Completed |
NCT03132727 -
Interest of MRI in Preoperative Staging for the Laryngeal and Hypopharyngeal Cancer
|
||
| Recruiting |
NCT06080503 -
Phase II Randomized Study of Hypofractionated Versus Conventional Radiotherapy
|
N/A | |
| Not yet recruiting |
NCT05568641 -
Vitamin-D Receptor in Laryngeal Squamous Cell Carcinoma
|
||
| Recruiting |
NCT05075980 -
HEADLIGHT: Hypofractionated Proton Therapy for Head and Neck Cancers
|
Phase 2 | |
| Recruiting |
NCT06463756 -
CT-based Radiomics and Deep Learning Models to Predict Thyroid Cartilage Invasion and Patient Prognosis in Laryngeal Carcinoma
|
||
| Terminated |
NCT02062632 -
Doxepin Hydrochloride in Treating Esophageal Pain in Patients With Thoracic Cancer Receiving Radiation Therapy to the Thorax With or Without Chemotherapy
|
Phase 2 |