Intraoperative PEEP Setting During Laparoscopic Gynecologic Surgery

Status Completed

Clinical Trial Summary

The creation of pneumoperitoneum during laparoscopic surgery can have significant effects on the respiratory system including decreased respiratory system compliance, decreased vital capacity and functional residual capacity and atelectasis formation. Intraoperative mechanical ventilation, especially setting of positive end-expiratory pressure (PEEP) has an important role in respiratory management during laparoscopic surgery. The aim of this study is to determine whether setting of PEEP guided by measurement of pleural pressure would improve oxygenation and respiratory system compliance during laparoscopic surgery.

Clinical Trial Description

As minimally invasive procedure with numerous advantages compared with open surgery, laparoscopic surgery has been substantially performed worldwide. The creation of pneumoperitoneum during laparoscopic surgery, however, can have significant effects on the respiratory system including decreased respiratory system compliance, decreased vital capacity and functional residual capacity and atelectasis formation. These pathophysiologic changes may put patients at risk of postoperative pulmonary complications. Therefore, intraoperative mechanical ventilation, especially setting of positive end-expiratory pressure (PEEP) has an important role in respiratory management during laparoscopic surgery. Nevertheless, there is no consensus on the optimal PEEP level and the best method to set PEEP during laparoscopic surgery. In patients with acute respiratory distress syndrome, PEEP set according to pleural pressure measured by using esophageal balloon catheter significantly has beneficial effects in terms of oxygenation, compliance and possible mortality. The aim of this study is to determine whether setting of PEEP guided by measurement of pleural pressure would improve oxygenation and respiratory system compliance during laparoscopic surgery. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03256396
Study type	Interventional
Source	Mahidol University
Contact
Status	Completed
Phase	N/A
Start date	March 30, 2018
Completion date	December 28, 2018

View Details

See also
Status	Clinical Trial	Phase
Not yet recruiting	`NCT04515485` - A Volumetric Nomogram for Height, Weight, and Intra Abdominal Volume
Completed	`NCT01725477` - Laparoscopic Tubal Patency Assessment	N/A
Recruiting	`NCT01093079` - Laparoscopic Versus Open Partial Nephrectomy - Surgical and Oncological Outcomes	N/A
Recruiting	`NCT01093430` - Is the Anterior Superior Iliac Spine a Useful Landmark at Laparoscopy?	N/A
Completed	`NCT01092013` - Comparative Evaluation of Simulator Based and Traditional In-surgery Laparoscopic Camera Training's Efficiency in Novices	N/A
Completed	`NCT00535990` - Minimally Invasive Surgery (MIS) Database for the Purpose of Research
Recruiting	`NCT06044909` - Multimodal Image Registration for Helping Laparoscopic Liver Surgery Guidance
Not yet recruiting	`NCT05389241` - Laparoscopic Augmented Reality for Identification of Liver Lesions - a Pre-clinical Randomized Cross-over Trial	N/A
Completed	`NCT06255080` - Comparing Skills Acquisition on Different Laparoscopy Software	N/A
Enrolling by invitation	`NCT03234543` - Remote Ischemic Conditioning in Abdominal Surgery	N/A
Recruiting	`NCT02827292` - Effect of Music on Inflammatory Response During Laparoscopic Surgery	N/A
Not yet recruiting	`NCT06092684` - The Efficacy and Safety of Esketamine in Elective Laparoscopic Surgery	Phase 3
Terminated	`NCT01008709` - Comparison Study of Two Different Surgical Clips During Laparoscopic Urologic Surgery	N/A
Active, not recruiting	`NCT05363813` - Post-market Clinical Follow-up Study of Reusable Clip Applier Cartridge Devices for LAParoscopic Surgery	N/A
Completed	`NCT03330236` - EEG - Guided Anesthetic Care and Postoperative Delirium	N/A
Recruiting	`NCT05031182` - Tolerance of the vNOTES Surgical Technique in Total Hysterectomy for Benign Lesion. Clinical Trial of Non-inferiority Compared to the Laparoscopic Technique.	N/A
Active, not recruiting	`NCT05302622` - Detecting the Most Efficient Residency Time for Laparoscopic Simulators	N/A
Recruiting	`NCT03684291` - Hemodynamic Effects of Ventilation Modes
Recruiting	`NCT06117748` - Volume-Controlled Ventilation and Pressure-Controlled Ventilation Volume Guaranteed in Obese Patients in Laparoscopic-Assisted Surgery	N/A
Recruiting	`NCT03739944` - Different Surgical Approaches in Patients of Early-stage Cervical Cancer	Phase 3

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.